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US Patent 10174005 Fused pyrimidines as inhibitors of p97 complex

Patent 10174005 was granted and assigned to Cleave Biosciences, Inc. on January, 2019 by the United States Patent and Trademark Office.

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Patent
Patent

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Patent Applicant
Cleave Biosciences, Inc.
Cleave Biosciences, Inc.
Current Assignee
Cleave Biosciences, Inc.
Cleave Biosciences, Inc.
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
10174005
Date of Patent
January 8, 2019
Patent Application Number
15792514
Date Filed
October 24, 2017
Patent Primary Examiner
‌
Bruck Kifle
Patent abstract

The present invention is directed to certain fused pyrimidines having a homo or hetero cyclopentyl, cyclohexyl or cycloheptyl ring as the pyrimidine fusion partner; having an amino benzyl or substituted amino benzyl group at the 4 position of the pyrimidine ring; and a 5:6 heterobicyclo ring with at least one N, O or S at the 2 position of the pyrimidine ring. These compounds are useful for treatment of cancer by inhibition of the p97 complex.

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