eGenesis' state goal is to make xenotransplantation a routine medical procedure. The company is a Cambridge, MA-based startup that's using the gene-editing tool CRISPR to make pig organs viable for transplants into people.
The company raised $38 million in March 2017 and is cofounded by Harvard geneticist George Church and Luhan Yang. Their research is focusing on removing certain genes in pigs that could cause diseases or organ rejection in humans, making it possible for those pig organs to be transplanted. eGenesis announced in the journal Science that it had produced 37 piglets that had inactivated Porcine Endogenous Retrovirus, or PERV.
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- CRISPRClustered regularly interspaced short palindromic repeats (CRISPR) is a prokaryotic adaptive immune response that provides immunity against foreign nucleic acids, such as viral DNA and bacterial plasmids, through the use of crRNAs (CRISPR RNAs) and associated Cas genes.
- George ChurchAn American genetic scientist and Harvard University professor.