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ZIOPHARM Oncology

ZIOPHARM Oncology

ZIOPHARM Oncology is a biotechnology company developing cancer therapies.

ZIOPHARM Oncology is a biotechnology company developing gene therapy, cell therapy and cancer immunotherapy products that is headquartered in Boston, Massachusetts and was founded in 2005 by Jonathan Lewis.



Ziopharm is developing immunotherapies using Controlled IL-12, which weaponizes the existing immune system and Sleeping Beauty-modified T cells, which introduces new immune system elements to fight cancer. 

Products

Controlled IL-12

Controlled IL-12 targets cold tumors, those the exhibit little or no immune system activity, and turns them “hot” by calling in an immune response. As a monotherapy and in combination with checkpoint inhibitors it is being developed to treat brain cancer and the therapeutic potential of other solid tumors is being explored. 



The Controlled IL-12 therapeutic introduces the cytokine and immune system regulator, IL-12 plus the drug veledimex as a gene therapy with an Adenoviral vector. IL-12 is expressed in cells under the control of the RheoSwitch Therapeutic System. Veledimex triggers the implanted IL-12 genes to produce IL-12 protein at a controlled dosage, which can also be turned off. IL-12 acts as a beacon to signal T cells to attack and destroy cancerous tissue. 

Sleeping Beauty-modified T cells

Sleeping Beauty is a technology Ziopharm is using to develop non-viral cell therapies such as genetically modified chimeric antigen receptors (CARs) and T-cell receptors (TCRs) which target tumor-derived antigens. The technology does not require ex vivo T-cell expansion, so the patient can be treated in a shorter frame of time. Sleeping Beauty can be used to target multiple antigens and has options for blood cancers and solid tumors.



The Sleeping Beauty platform genetically modifies T cells with DNA plasmids to express T-cell receptors (TCRs) and to target specific antigens in solid tumors and chimeric antigen receptors (CARs). The platform is being advanced with collaboration from the National Cancer Institute, The University of Texas MD Anderson Cancer Center and Eden BioCell.

Timeline

September 12, 2019

Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System

Mol Ther. 2016 Jun;24(6):1078-1089

July 2, 2019

Study of Ad-RTS-hIL-12 + Veledimex in Combination With Cemiplimab in Subjects With Recurrent or Progressive Glioblastoma - Full Text View - ClinicalTrials.gov

June 2019

Ziopharm Oncology Announces FDA Clearance of IND for Sleeping Beauty TCR-T Cell Therapy Trial at NCI

(Nasdaq: ZIOP) announced that the investigational new drug (IND) application submitted by the National Cancer Institute (NCI) has received clearance from the U.S. Food and Drug Administration (FDA) for a clinical trial in solid tumors to evaluate T-cell receptor (TCR) T-cell utilizing Ziopharm’s Sleeping Beauty platform.

Funding rounds

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People

Name
Role
LinkedIn

Charles Yoo

Employee



Eleanor (Ellee) de Groot, Ph.D.

EVP, GM CELL THERAPY



Folake Ogundiran

Employee



Frank R Codispoti

Investor



Hartman King

Investor



Jill Buck

EVP, GM GENE THERAPY



Jonathan Lewis

Founder



Judy Carmody, Ph.D ~ Executive Quality Consultant

Employee



Kyle DiFiore

Investor



Laurence J.N. Cooper, M.D., Ph.D.

President



Laurence J.N. Cooper, M.D., Ph.D.

EVP, GENERAL COUNSEL, SECRETARY AND CHIEF COMPLIANCE OFFICER



Laurence J.N. Cooper, M.D., Ph.D.

CEO



Lynn M. Ferrucci

EVP, HUMAN RESOURCES, FACILITIES, ADMINISTRATION AND IT



Satyavrat (Sath) Shukla, CFA

CFO



Steven Kellman

Investor



Steven Zeppenfeld

Investor



Further reading

Title
Author
Link
Type
Date

Sleeping Beauty Awakens for Genome Engineering

Emma Markham

Web



Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System



Web



ZIOPHARM Announces Presentation of Data from T-Cell Therapy Programs at ASH Annual Meeting | ZIOPHARM Oncology, Inc.

Ziopharm

Web



Documentaries, videos and podcasts

Title
Date
Link

Laurence Cooper, CEO, Ziopharm Oncology

November 27, 2017

Companies

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References