Golden
YourChoice Therapeutics

YourChoice Therapeutics

YourChoice Therapeutics is a biotechnology company founded in 2018 is developing contraceptives for men and women. The technology for their non-hormonal contraceptive products arose from research at the University of California, Berkeley.

YourChoice Therapeutics was one of the 2018 CITRIS Foundry Startups. One of their technologies is a “molecular condom” concept where an active compound inhibits sperm motility preventing it from fertilizing the egg.The molecular target on the sperm is CatSper, a sperm-specific calcium ion channel that initiates a motility pattern called hyperactivation needed for fertilization. The research group discovered that the extracellular protein, ABHD2 that regulates CatSper activity can be bound by the plant-derived compound lupeol. This prevents the sperm from transitioning to hyperactivation and the affected sperm are incapable of fertilizing an egg.



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People

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Akash Bakshi

Co-Founder, CEO



Nadja Mannowetz

Co-Founder, CSO



POLINA LISHKO

Founder, Consultant



Further reading

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Regulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids



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