VistaGen Therapeutics is a publicly owned, clinical-stage biopharmaceutical company based in San Francisco, California that was founded in 1998 by Ralph Snodgrass. The company is focused on developing treatments for depression and other central nervous system (CNS) disorders including, major depressive disorder, neuropathic pain, social anxiety disorder, and suicidal ideation.
VistaGen's product pipeline consists of three items, AV-101, PH10, and PH94B. AV-101 is an oral NMDAR GlyB (N-methyl-D-aspartate receptor glycine B) antagonist, which is a type of glutamate receptor modulators having the potential to treat MDD. Phase 2 clinical trials designed to evaluate the efficacy and safety of it's adjunctive use is ongoing. The US FDA has granted Fast Track designation for AV-101 as both a potential adjunctive treatment of MDD and as a non-opiod treatment for neuropathic pain. The company has also received Notices of Allowances from IP Australia and the Japan Patent Office (JPO) .
PH94B is an intranasal treatment for the rapid onset, on demand treatment of social anxiety disorder (SAD) symptoms. The treatment is developed from VistaGen's proprietary compounds called pherines. Another treatment being developed from pherines, is PH10, which activates nasal chemosensory receptors that in turn engage GABA (gamm-aminubutyic acid) and CRH (corticotropin-releasing hormones) neurons in the hypothalamus, amygdala, prefrontal cortex, and hippocampus. As another potential treatment for MDD, VistaGen is preparing to advance PG10's development in Phase 2b clinical trials.
H. Ralph Snodgrass
Founder, President, Director & Chief Scientific Officer
Jerrold D. Dotson
VP & CFO and Secretary
Mark A. McPartland
VP of Corporate Development
Mark A. Smith
Chief Medical Officer
Shawn K. Singh
Director & CEO
Susan E Caldwell, PhD
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VistaGen Therapeutics, Inc.
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- BiotechnologyBiotechnology can refer to the application of science and technology to living organisms or the use of living organisms, their parts, products or models thereof to solve a problem, produce knowledge or produce goods and services. Biotechnology may involve the alteration of living or non-living materials.
- CompanyA company, abbreviated as "Co." within a company name, is a legal entity made up of an association of people, be they natural, legal, or a mixture of both, for carrying on a commercial or industrial enterprise.
- Major depressive disorderAn endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities.
- Social anxiety disorderA phobic disorder that involves social anxiety occurring only in specific public or social situations, interactions with others or being evaluated or scrutinized by other people.