Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Oscar Miguel Moradei0
Robert E. Babine0
Gideon Shapiro0
Lei Jin0
Richard Chesworth0
Date of Patent
August 22, 2017
Patent Application Number
14775766
Date Filed
March 14, 2014
Patent Citations Received
Patent Primary Examiner
Patent abstract
Provided herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R1, R1a, R2a, R2b, R2c, R2d, are as defined herein, and Ring HET is a 6-membered monocyclic heteroaryl ring system of Formula (II) wherein L2, R13, G8, G10, G11, and G12 are as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.
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