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US Patent 9365635 Intravenous immunoglobulin composition

Patent 9365635 was granted and assigned to Omrix Biopharmaceuticals on June, 2016 by the United States Patent and Trademark Office.

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Patent
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Patent attributes

Current Assignee
Omrix Biopharmaceuticals
Omrix Biopharmaceuticals
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
93656350
Patent Inventor Names
Orgad Laub0
Israel Nur0
Liliana Bar0
Date of Patent
June 14, 2016
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Patent Application Number
136190110
Date Filed
September 14, 2012
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Patent Primary Examiner
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Benjamin P Blumel
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Patent abstract

A concentrated, immunoglobulin composition for treating subjects vaccinated against or infected with a pathogenic microorganism, is made by (a) selecting a population of individuals previously vaccinated against antigens associated with the pathogenic microorganism; (b) identifying very high titer individuals by determining the level of specific antibodies immunoreactive with the pathogenic microorganism in the blood of the individuals; (c) combining blood from the very high titer individuals; and (d) purifying and/or concentrating the product of step (c). A concentrated immunoglobulin composition can include specific antibodies immunoreactive with a pathogenic microorganism, wherein the titer of specific antibodies is at least 5 times higher than the average titer of specific antibodies of a population of individuals previously vaccinated against antigens associated with the pathogenic microorganism. The composition has a relatively high protein concentration and a low percentage of protein aggregates. The pathogenic microorganism is preferably smallpox virus or vaccinia virus.

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