Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
George Barany0
Matthew Lubin0
Phillip Belgrader0
Robert P. Hammer0
Francis Barany0
Date of Patent
August 29, 2006
0Patent Application Number
108522890
Date Filed
May 24, 2004
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention relates to the detection of nucleic acid sequence differences using coupled ligase detection reaction and polymerase chain reaction. One aspect of the present invention involves use of a ligase detection reaction coupled to a polymerase chain reaction. Another aspect of the present invention relates to the use of a primary polymerase chain reaction coupled to a secondary polymerase chain reaction coupled to a ligase detection reaction. A third aspect of the present invention involves a primary polymerase chain reaction coupled to a secondary polymerase chain reaction. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence differences.
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