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US Patent 7078180 Methods and compositions useful for diagnosis, staging, and treatment of cancers and tumors

Patent 7078180 was granted and assigned to The Children'S Hospital Of Philadelphia on July, 2006 by the United States Patent and Trademark Office.

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Current Assignee
The Children'S Hospital Of Philadelphia
The Children'S Hospital Of Philadelphia
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
70781800
Patent Inventor Names
Thomas Genetta0
Date of Patent
July 18, 2006
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Patent Application Number
102325610
Date Filed
August 30, 2002
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Patent Citations Received
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US Patent 11965877 Compositions and methods for molecular labeling
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US Patent 12125691 Systems and methods for sample analysis using swabs
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US Patent 12091710 Systems and methods for handling microfluidic droplets
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US Patent 11821109 Compartmentalised combinatorial chemistry by microfluidic control
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Patent Primary Examiner
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Sheela J. Huff
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Patent abstract

Methods, compositions and kits which employ one or more ZEB specific detection reagents for detection and localization of ZEB associated molecules in tumor cells are disclosed. Also provided are methods for determining stage and progression of cancer in a mammal based on alterations in ZEB expression levels and subcellular localization. Also provided are methods for treating a cancer in a mammal by modulating ZEB expression levels and activity.

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