Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Pinchas Tsukerman0
Ofer Mandelboim0
Stipan Jonjic0
Noa S. Kaynan0
Date of Patent
October 22, 2024
0Patent Application Number
171684510
Date Filed
February 5, 2021
0Patent Citations
0
Patent Primary Examiner
Patent abstract
Natural killer (NK) cell killing of various tumors is inhibited in the presence of ligands of TIGIT, an inhibitory receptor present on all human NK cells and on various T cells. Monoclonal antibodies that recognize TIGIT and inhibit its suppressive activity on T-cells are provided as well as pharmaceutical compositions comprising them and methods for their use in cancer immunotherapy and in diagnosis and treatment of immune disorders.
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