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US Patent 12065478 HER2-targeting antigen binding molecules comprising 4-1BBL

Patent 12065478 was granted and assigned to Hoffmann-La Roche Limited on August, 2024 by the United States Patent and Trademark Office.

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Is a
Patent
Patent
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Patent attributes

Patent Applicant
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Hoffmann-La Roche Limited
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Current Assignee
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Hoffmann-La Roche Limited
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
120654780
Patent Inventor Names
Christina Claus0
Teemu Tapani Junttila0
Christian Klein0
Claudia Ferrara Koller0
Pablo Umana0
Date of Patent
August 20, 2024
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Patent Application Number
170667110
Date Filed
October 9, 2020
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Patent Citations
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US Patent 7332581 Polypeptide variants with altered effector function
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US Patent 7521541 Cysteine engineered antibodies and conjugates
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US Patent 7527791 Humanized anti-TGF-beta antibodies
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US Patent 7560111 HER2 antibody composition
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US Patent 7659384 Polynucleotides encoding fully human antibodies against human 4-1BB
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US Patent 7695936 Knobs and holes heteromeric polypeptides
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US Patent 9758582 Anti-CTLA4 antibody-TGF-βRII targeted/immunomodulatory fusion proteins
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US Patent 10155815 Bispecific T cell activating antigen binding molecules
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Patent Primary Examiner
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Laura B Goddard
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Patent abstract

The invention relates to Her2 targeting 4-1BB agonists, in particular 4-1BBL trimer-containing antigen binding molecules comprising at least one antigen binding domain capable of specific binding to Her2 and their use in the treatment of cancer as well as their use in combination with T-cell activating anti-CD3 bispecific antibodies.

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