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US Patent 12016932 Gene editing for hemophilia A with improved factor VIII expression

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Is a
Patent
Patent
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Patent attributes

Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
120169320
Patent Inventor Names
Alan Richard Brooks0
Date of Patent
June 25, 2024
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Patent Application Number
180558230
Date Filed
November 15, 2022
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Patent Citations
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US Patent 10654910 Factor VIII proteins having ancestral sequences, expression vectors, and uses related thereto
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US Patent 10709796 Optimised coding sequence and promoter
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US Patent 7041635 Factor VIII polypeptide
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US Patent 10124041 Methods of delivering factor VIII encoding nucleic acid sequences
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US Patent 10143760 Liver-specific constructs, factor VIII expression cassettes and methods of use thereof
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US Patent 10189888 Viral vectors encoding recombinant FVIII variants with increased expression for gene therapy of hemophilia A
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US Patent 10189889 Viral vectors encoding recombinant FVIII variants with increased expression for gene therapy of hemophilia A
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US Patent 10272163 Factor VIII mutation repair and tolerance induction
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...
Patent Primary Examiner
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Amy Rose Hudson
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CPC Code
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C12N 15/111
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C12N 2310/20
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Patent abstract

Provided herein, in some embodiments, are materials and methods for treating hemophilia A in a subject ex vivo or in vivo. Also provided herein, in some embodiments, are materials and methods for knocking in a coding sequence encoding a synthetic FVIII having a B domain substitute into a genome.

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