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US Patent 11987644 Method of manufacturing bispecific antibodies, bispecific antibodies and therapeutic use of such antibodies

Patent 11987644 was granted and assigned to Novartis on May, 2024 by the United States Patent and Trademark Office.

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Patent Applicant

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Current Assignee

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Jiri Kovarik0

Hans-Peter Knopf0

Dhavalkumar Patel0

Rolf Koehler0

Christian Graf0

Stephen John Oliver0

Michael Otto Bardroff0

Tina Buch0

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Date of Patent

May 21, 2024

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Patent Application Number

168449990

Date Filed

April 9, 2020

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Patent Citations

US Patent 9527927 Modified polypeptides for bispecific antibody scaffolds

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US Patent 7993878 Antibodies to human IL-1β

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US Patent 9212230 Bispecific antibodies and methods for production thereof

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US Patent 9376489 IL-18 binding molecules

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US Patent 10882922 Trispecific and/or trivalent binding proteins

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Patent Primary Examiner

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Patent abstract

The invention relates to bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof, and methods of manufacturing such antibodies by co-expressing modified Fc-mutated derivatives of two different monoclonal antibodies in mammalian cell lines.

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