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US Patent 11965012 Compositions and methods for TCR reprogramming using fusion proteins

Patent 11965012 was granted and assigned to Tcr2 Therapeutics Inc. on April, 2024 by the United States Patent and Trademark Office.

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Patent
Patent
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Patent attributes

Patent Applicant
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Tcr2 Therapeutics Inc.
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Current Assignee
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Tcr2 Therapeutics Inc.
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
119650120
Patent Inventor Names
Gregory Sieczkiewicz0
Robert Hofmeister0
Patrick Baeuerle0
Date of Patent
April 23, 2024
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Patent Application Number
180697490
Date Filed
December 21, 2022
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Patent Citations
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US Patent 7067318 Methods for transfecting T cells
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US Patent 7081518 Anti-mesothelin antibodies having high binding affinity
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US Patent 7144575 Methods for selectively stimulating proliferation of T cells
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US Patent 7172869 Methods for transfecting T cells
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US Patent 7175843 Methods for selectively stimulating proliferation of T cells
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US Patent 7232566 Methods for treating HIV infected subjects
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US Patent 7371849 Methods of constructing camel antibody libraries
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US Patent 7572631 Activation and expansion of T cells
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Patent Primary Examiner
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Zachary S Skelding
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Patent abstract

Provided herein are T-cell receptor (TCR) fusion proteins (TFPs), T-cells engineered to express one or more TFPs, and methods of use thereof for the treatment of diseases, including cancer.

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