GoldenGolden
Advanced Search
Synthetic biology

Synthetic biology

Interdisciplinary branch of biology and engineering, applying multiple disciplines to build artificial biological systems for research, engineering, and medical applications.

All edits

Edits on 17 Aug, 2021
Jude Gomila
Jude Gomila edited on 17 Aug, 2021
Edits made to:
Infobox (+1 properties)
Infobox
Parent industry
Biology
Edits on 14 Jul, 2020
Carla Faraguna
Carla Faraguna approved a suggestion from Golden's AI on 14 Jul, 2020
Edits made to:
Article (+14/-14 characters)
Article

Similar tools are used in genetic engineering, genome editinggenome editing and synthetic biology and a line is sometimes drawn between synthetic biology and the former disciplines by the much larger scale of the manipulations being performed in synthetic biology. Enhancing photosynthesis and growth of plants is a research area that used both genetic engineering and synthetic biology. Many biological building blocks are interchangeable between cyanobacteria, algae and plants and swapping homologous photosynthetic proteins between species would be genetic engineering. Synthetic biology approaches would involve the exchange of entire multiprotein complexes between distantly related species. Synthetic biology involves building using standardized genetic parts and synthetic biological circuit design.

Edits on 8 Jul, 2020
Carla Faraguna
Carla Faraguna approved a suggestion from Golden's AI on 8 Jul, 2020
Edits made to:
Article (+15/-15 characters)
Article

Biophysicist Stéphane LeducStéphane Leduc coined the term synthetic biology and laid out the philosophical and experimental foundations in 1912. Leduc argued that no boundary separates life from physical phenomena, illustrating this by growing chemical gardens of inorganic crystals that resemble living systems. The theoretical basis of contemporary synthetic biology is largely attributed to Waclaw Szybalski,’s statements in 1974 related to the invention recombinant DNA technology.

Edits on 7 Jul, 2020
Meredith Hanel
Meredith Hanel edited on 7 Jul, 2020
Edits made to:
Article (+4/-3 characters)
Article

Biophysicist Stéphane Leduc coined the term synthetic biology and laid out the philosophical and experimental foundations in 1912. Leduc argued thethat no boundary separates life from physical phenomena, illustrating this by growing chemical gardens of inorganic crystals that resemble living systems. The theoretical basis of contemporary synthetic biology is largely attributed to Waclaw Szybalski,’s statements in 1974 related to the invention recombinant DNA technology.

Carla Faraguna
Carla Faraguna approved a suggestion from Golden's AI on 7 Jul, 2020
Edits made to:
Article (+20/-20 characters)
Article

Rather than a biophysical discipline, contemporary synthetic biology is largely an engineering discipline that emphasizes principles such as standardization, modularity, digital logic and mathematically predictable behavior. Synthetic biology as an engineering discipline began being discussed around 2005-2006. A possible hierarchy for synthetic biology inspired by computer engineeringcomputer engineering, was described by researchers at Princeton University. DNA, RNA, proteins and metabolites are analogous to the physical layer of transistors, capacitors and resistors. Biochemical reactions that regulate the flow of information and manipulate physical process are analogous to the device layer with logic gates. It is envisioned that synthetic biologist would assemble biological devices into pathways that function like integrated circuits.

Edits on 3 Jul, 2020
Jason D. Rowley
Jason D. Rowley approved a suggestion from Golden's AI on 3 Jul, 2020
Edits made to:
Article (+20/-20 characters)
Article

Rather than a biophysical discipline, contemporary synthetic biology is largely an engineering discipline that emphasizes principles such as standardization, modularity, digital logic and mathematically predictable behavior. Synthetic biology as an engineering discipline began being discussed around 2005-2006. A possible hierarchy for synthetic biology inspired by computer engineering, was described by researchers at Princeton UniversityPrinceton University. DNA, RNA, proteins and metabolites are analogous to the physical layer of transistors, capacitors and resistors. Biochemical reactions that regulate the flow of information and manipulate physical process are analogous to the device layer with logic gates. It is envisioned that synthetic biologist would assemble biological devices into pathways that function like integrated circuits.

Rory Gilchrist
Rory Gilchrist approved a suggestion from Golden's AI on 2 Jul, 2020
Edits made to:
Article (+17/-17 characters)
Article
Up to now we are working on the descriptive phase of molecular biologymolecular biology. ... But the real challenge will start when we enter the synthetic biology phase of research in our field. We will then devise new control elements and add these new modules to the existing genomes or build up wholly new genomes. This would be a field with unlimited expansion potential and hardly any limitations to building ‘new better control circuits’ and ... finally other ‘synthetic’ organisms ...
Edits on 29 Jun, 2020
Meredith Hanel
Meredith Hanel edited on 29 Jun, 2020
Edits made to:
Article (+63/-82 characters)
Article

Drew Endy, a civil engineer, and fellow researchers at MIT are recognized at major contributors to synthetic biology and brought forth the BioBricks Foundation dedicated to developing the approach of using the engineering mindset of standardized interchangeable biological parts. Endy and his colleagues also laid the groundwork for the international Genetically Engineered Machines Competition (iGEM), which began as an MIT summer course in 2003. Jay Keasling at University of California, Berkeley contributed to the framing of synthetic biology as a new engineering discipline by engineering yeast to produce artemisinin, used in malaria drugs in 2006. Another contributor to the synthetic biology field is Craig Venters with his work deconstructing micro-organisms in order to find the minimal amount of genetic material needed for a living cell and building a fully synthetic genome, is also one of the main initial contributors to the synthetic biology movement.

Meredith Hanel
Meredith Hanel edited on 29 Jun, 2020
Edits made to:
Article (+10/-9 characters)
Article

Drew Endy, a civil engineer, and fellow researchers at MIT are recognized at major contributors to synthetic biology and brought forth the BioBricks Foundation dedicated to developing the approach of using the engineering mindset of standardized interchangeable biological parts. Endy and his colleaguecolleagues also laid the groundwork for the international Genetically Engineered Machines Competition (iGEM), which began as an MIT summer course in 2003. Jay Keasling at University of California, Berkeley contributed to the framing of synthetic biology as a new engineering discipline by engineering yeast to produce artemisinin, used in malaria drugs in 2006. Craig Venter’s work deconstructing micro-organisms in order to find the minimal amount of genetic material needed for a living cell and building a fully synthetic genome, is also one of the main initial contributors to the synthetic biology movement.

Meredith Hanel
Meredith Hanel edited on 29 Jun, 2020
Edits made to:
Article (+2377/-830 characters)
Article

Biophysicist Stéphane Leduc coined the term synthetic biology and laid out the philosophical and experimental foundations in 1912. Leduc argued the no boundary separates life from physical phenomena, illustrating this by growing chemical gardens of inorganic crystals that resemble living systems. The theoretical basis of contemporary synthetic biology is largely attributed to Waclaw Szybalski,’s statements in 1974 related to the invention recombinant DNA technology.

Up to now we are working on the descriptive phase of molecular biology. … But the real challenge will start when we enter the synthetic biology phase of research in our field. We will then devise new control elements and add these new modules to the existing genomes or build up wholly new genomes. This would be a field with unlimited expansion potential and hardly any limitations to building ‘new better control circuits’ and … finally other ‘synthetic’ organisms …
...

Rather than a biophysical discipline, contemporary synthetic biology is largely an engineering discipline that emphasizes principles such as standardization, modularity, digital logic and mathematically predictable behavior.

Rather than a biophysical discipline, contemporary synthetic biology is largely an engineering discipline that emphasizes principles such as standardization, modularity, digital logic and mathematically predictable behavior. Synthetic biology as an engineering discipline began being discussed around 2005-2006. A possible hierarchy for synthetic biology inspired by computer engineering, was described by researchers at Princeton University. DNA, RNA, proteins and metabolites are analogous to the physical layer of transistors, capacitors and resistors. Biochemical reactions that regulate the flow of information and manipulate physical process are analogous to the device layer with logic gates. It is envisioned that synthetic biologist would assemble biological devices into pathways that function like integrated circuits.

...

Synthetic biology as an engineering discipline began being discussed around 2005-2006. A possible hierarchy for synthetic biology inspired by computer engineering, was described by researchers at Princeton University. DNA, RNA, proteins and metabolites are analogous to the physical layer of transistors, capacitors and resistors. Biochemical reactions that regulate the flow of information and manipulate physical process are analogous to the device layer with logic gates. It is envisioned that synthetic biologist would assemble biological devices into pathways that function like integrated circuits.

Drew Endy, a civil engineer, and fellow researchers at MIT are recognized at major contributors to synthetic biology and brought forth the BioBricks Foundation dedicated to developing the approach of using the engineering mindset of standardized interchangeable biological parts. Endy and his colleague also laid the groundwork for the international Genetically Engineered Machines Competition (iGEM), which began as an MIT summer course in 2003. Jay Keasling at University of California, Berkeley contributed to the framing of synthetic biology as a new engineering discipline by engineering yeast to produce artemisinin, used in malaria drugs in 2006. Craig Venter’s work deconstructing micro-organisms in order to find the minimal amount of genetic material needed for a living cell and building a fully synthetic genome, is also one of the main initial contributors to the synthetic biology movement.

Meredith Hanel
Meredith Hanel edited on 29 Jun, 2020
Edits made to:
Timeline (+1 events) (+75 characters)
Article (+1135 characters)
Article
History

Biophysicist Stéphane Leduc coined the term synthetic biology and laid out the philosophical and experimental foundations in 1912. Leduc argued the no boundary separates life from physical phenomena, illustrating this by growing chemical gardens of inorganic crystals that resemble living systems.

Rather than a biophysical discipline, contemporary synthetic biology is largely an engineering discipline that emphasizes principles such as standardization, modularity, digital logic and mathematically predictable behavior.

Synthetic biology as an engineering discipline began being discussed around 2005-2006. A possible hierarchy for synthetic biology inspired by computer engineering, was described by researchers at Princeton University. DNA, RNA, proteins and metabolites are analogous to the physical layer of transistors, capacitors and resistors. Biochemical reactions that regulate the flow of information and manipulate physical process are analogous to the device layer with logic gates. It is envisioned that synthetic biologist would assemble biological devices into pathways that function like integrated circuits.

Timeline

June 29, 1912

The term synthetic biology was coined by French biophysicist Stéphane Leduc
Edits on 28 Jun, 2020
Meredith Hanel
Meredith Hanel approved a suggestion from Golden's AI on 28 Jun, 2020
Edits made to:
Article (+15/-15 characters)
Article

Synthetic biology is not only an applied discipline but also a fundamental discipline. For example, the construction of the minimal bacterial genome, the synthetic yeast project and parts of the Genome Project-write initiative do not have direct applications but aim to advance our knowledge of genomes. The synthetic biology community has a mindset that is influenced by the phrase by theoretical physicist Richard FeynmanRichard Feynman, “What I cannot create, I do not understand”. The concept is that using fundamental principles it should be possible to build up or understand an idea, proof or concept from the ground up. The idea of understanding by synthesis is a major theme in synthetic biology. Synthetic approaches have not been used in biology to the extent they have been used in other disciplines, such as gaining an understanding of the laws of chemistry through chemical synthesis.

Meredith Hanel
Meredith Hanel approved a suggestion from Golden's AI on 28 Jun, 2020
Edits made to:
Article (+19/-19 characters)
Article

Similar tools are used in genetic engineeringgenetic engineering, genome editing and synthetic biology and a line is sometimes drawn between synthetic biology and the former disciplines by the much larger scale of the manipulations being performed in synthetic biology. Enhancing photosynthesis and growth of plants is a research area that used both genetic engineering and synthetic biology. Many biological building blocks are interchangeable between cyanobacteria, algae and plants and swapping homologous photosynthetic proteins between species would be genetic engineering. Synthetic biology approaches would involve the exchange of entire multiprotein complexes between distantly related species. Synthetic biology involves building using standardized genetic parts and synthetic biological circuit design.

Edits on 26 Jun, 2020
Meredith Hanel
Meredith Hanel edited on 26 Jun, 2020
Edits made to:
Article (+9 characters)
Article

Synthetic biology is not only an applied discipline but also a fundamental discipline. For example, the construction of the minimal bacterial genome, the synthetic yeast project and parts of the Genome Project-write initiative do not have direct applications but aim to advance our knowledge of genomes. The synthetic biology community has a mindset that is influenced by the phrase by theoretical physicist Richard Feynman, “What I cannot create, I do not understand”. The concept is that using fundamental principles it should be possible to build up or understand an idea, proof or concept from the ground up. The idea of understanding by synthesis is a major theme in synthetic biology. Synthetic approaches have not been used in biology to the extent they have been used in other disciplines, such as gaining an understanding of the laws of chemistry through chemical synthesis.

Meredith Hanel
Meredith Hanel edited on 26 Jun, 2020
Edits made to:
Article (+938 characters)
Article

Synthetic biology is the design and engineering of biologically based parts, novel devices and systems as well as the redesign of existing, natural biological systems. It has the potential to deliver important new applications and improve existing industrial processes, as it is applied to challenges in healthcare, agriculture, manufacturing and environmental protection and remediation. As a multidisciplinary field, synthetic biology brings together social scientists, biologists, chemists, engineers, mathematicians, and others to identify major challenges in society and collectively find solutions. Goals of synthetic biology include generating organisms that produce a substance such as medicine, agricultural products or fuel, metabolize pollutants, have the ability to sense something in the environment. Other applications include the generation of disease-resistant crops, tissue engineering and the building of engineered living materials that self-assemble or modulate the performance of a material. Please see Cluster: Synthetic biology for a collection of topics, tools, applications, organizations and companies related to synthetic biology.

...

Similar tools are used in genetic engineering, genome editing and synthetic biology and a line is sometimes drawn between synthetic biology and the former disciplines by the much larger scale of the manipulations being performed in synthetic biology. Enhancing photosynthesis and growth of plants is a research area that used both genetic engineering and synthetic biology. Many biological building blocks are interchangeable between cyanobacteria, algae and plants and swapping homologous photosynthetic proteins between species would be genetic engineering. Synthetic biology approaches would involve the exchange of entire multiprotein complexes between distantly related species. Synthetic biology involves building using standardized genetic parts and synthetic biological circuit design.

Meredith Hanel
Meredith Hanel edited on 26 Jun, 2020
Edits made to:
Article (+876 characters)
Article

Synthetic biology is not only an applied discipline but also a fundamental discipline. For example, the construction of the minimal bacterial genome, the synthetic yeast project and the Genome Project-write initiative do not have direct applications but aim to advance our knowledge of genomes. The synthetic biology community has a mindset that is influenced by the phrase by theoretical physicist Richard Feynman, “What I cannot create, I do not understand”. The concept is that using fundamental principles it should be possible to build up or understand an idea, proof or concept from the ground up. The idea of understanding by synthesis is a major theme in synthetic biology. Synthetic approaches have not been used in biology to the extent they have been used in other disciplines, such as gaining an understanding of the laws of chemistry through chemical synthesis.

Meredith Hanel
Meredith Hanel edited on 26 Jun, 2020
Edits made to:
Article (+2042/-1099 characters)
Article

Synthetic biology is the design and engineering of biologically based parts, novel devices and systems as well as the redesign of existing, natural biological systems. It has the potential to deliver important new applications and improve existing industrial processes - resulting in economic growth and job creation.

Synthetic biology is the design and engineering of biologically based parts, novel devices and systems as well as the redesign of existing, natural biological systems. It has the potential to deliver important new applications and improve existing industrial processes, as it is applied to challenges in healthcare, agriculture, manufacturing and environmental protection and remediation. As a multidisciplinary field, synthetic biology brings together social scientists, biologists, chemists, engineers, mathematicians, and others to identify major challenges in society and collectively find solutions. Goals of synthetic biology include generating organisms that produce a substance such as medicine, agricultural products or fuel, metabolize pollutants, have the ability to sense something in the environment. Other applications include the generation of disease-resistant crops, tissue engineering and the building of engineered living materials that self-assemble or modulate the performance of a material.

...

As a multidisciplinary field, synthetic biology brings together social scientists, biologists, chemists, engineers, mathematicians, and others to identify major challenges in society and collectively find solutions.

Synthetic biology uses two main working directions for the construction of artificial biological systems with tailored properties: The top-down approach and the bottom-up approach. The top-down approach starts from existing micro-organisms and the genome is manipulated and reduced based on acquired knowledge to achieve a desired property. The bottom-up approach begins at the molecular level from functional biological devices like genome, transcriptome, proteome, metabolome, and aims to assemble these biological parts into an artificial cell or synthetic cell. A biodesign platform being developed in synthetic biology uses design-build-test-iterate (or deploy) to create cells or organisms that produce novel materials or to create organisms that perform novel functions.

...

Synthetic biology uses two main working directions for the construction of artificial biological systems with tailored properties: The top-down approach and the bottom-up approach. The top-down approach starts from existing micro-organisms and the genome is manipulated and reduced based on acquired knowledge to achieve a desired property. The bottom-up approach begins at the molecular level from functional biological devices like genome, transcriptome, proteome, metabolome, and aims to assemble these biological parts into an artificial cell or synthetic cell.

Some governments have expressed concerns that synthetic biology could increase the number of agents of concern such as chemical and biological threats and require the development of detection, identification and monitoring systems as countermeasures.

Edits on 6 Mar, 2020
Golden AI"Attach Wikidata entity ID"
Golden AI edited on 6 Mar, 2020
Edits made to:
Infobox (+1 properties)
Infobox
Wikidata entity ID
Q862838
Edits on 26 Sep, 2019
Meredith Hanel
Meredith Hanel edited on 26 Sep, 2019
Edits made to:
Article (+18 characters)
Article

Synthetic biology uses two main working directions for the construction of artificial biological systems with tailored properties: The top-down approach and the bottom-up approach. The top-down approach starts from existing micro-organisms and the genome is manipulated and reduced based on acquired knowledge to achieve a desired property. The bottom-up approach begins at the molecular level from functional biological devices like genome, transcriptome, proteome, metabolome, and aims to assemble these biological parts into an artificial cell or synthetic cell.

Meredith Hanel
Meredith Hanel edited on 26 Sep, 2019
Edits made to:
Article (+548 characters)
Categories (+1 topics)
Article

Synthetic biology uses two main working directions for the construction of artificial biological systems with tailored properties: The top-down approach and the bottom-up approach. The top-down approach starts from existing micro-organisms and the genome is manipulated and reduced based on acquired knowledge to achieve a desired property. The bottom-up approach begins at the molecular level from functional biological devices like genome, transcriptome, proteome, metabolome, and aims to assemble these biological parts into an artificial cell.

Categories
Golden logo
Text is available under the Creative Commons Attribution-ShareAlike 4.0; additional terms apply. By using this site, you agree to our Terms & Conditions.