The company is also developing oral DNA vaccines for diseases such as COVID-19, or even genetic diseases. Some of their programs are designed to treat oncological diseases, ischemic heart disease, and other rare diseases. Symvivo is taking part in research and development to prevent COVID-19, and are utilizing their DNA vaccine candidate bacTRL-Spike.
BacTRL-Spike is designed to potentially protect large populations from various emergent pathogens faster than an injectable vaccine. The gene therapy is designed around the limitations of standard gene delivery systems such as accommodating larger and multi-genes, controlling immune responses, or even targeting tissues.
Within oncology, the platform allows for the colonization of solid hypoxic tumors and the establishment of living bio-factories within tumors, which re-programs the tumors physiology. With infectious diseases the platform provides a passage for a bacterial vector containing plasmid DNA.
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