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Spero Therapeutics

Spero Therapeutics

A biopharmaceutical company that develops treatments for multi-drug resistant (MDR) bacterial infection

Spero Therapeutics is a privately owned clinical-stage biopharmaceutical company headquartered in Cambridge Massachusetts. The company focuses on identifying, developing, and commercializing treatments for multi-drug resistant (MDR) bacterial infections.

Products

SPR994

Spero's lead product candidate is SPR994, which is designed to be the first oral carbapenem-class antibiotic for use in adults to treat MDR Gram-negative infections, especially complicated urinary tract infections (cUTI). The treatment is derived from tebipenem, an antibiotic produced by Meiji Seika Pharma in Japan, which is used to treat common pediatric infections including pneumonia, otitis media, and sinusitis.

SPR741

Spero is also pursuing a couple of product candidates through its IV Potentiator Platform. SPR741 is an IV product that when combined with an antibiotic, has demonstrated the ability to expand the spectrum and potency of the co-administered antibiotic against Gram-negative bacteria.

SPR206

It has completed Phase 1A and 1B clinical trials highlighting its tolerability and pharmacokinetic profile. SPR206 is an IV direct-acting antibiotic that has shown activity against Acinetobacter baumanii and Pseudomonas aeruginosa in preclinical studies. It has completed non-clinical, IND enabling studies supporting its advancement as a clinical candidate to treat MDR and extensively drug-resistant (XDR) bacterial strains.

SPR720

Spero has another product candidate, SPR720, in very early stages. It is an oral therapy designed for the treatment of pulmonary non-tuberculous mycobacterial (NTM) infections. In November 2018, the company announced positive results from its IND-enabling studies and intends to initiate Phase 1 clinical trials in early 2019.

Timeline

People

Name
Role
Related Golden topics

Ankit Mahadevia

President & CEO



Carol Waldo

Head of Regulatory Affairs



Christina Larkin

COO



David Melnick

Chief Medical Officer



Ian A. Critchley

Head of Clinical Microbiology



Jay Blackington

Head of People Strategy and Culture



Joel Sendek

CFO



Melissa Stundick

Executive Director of Strategic Alliances



Michael Pucci

Executive Director - Early Drug Discovery



Steve Garbacz

Senior VP of Finance and Operations



Susannah Walpole

Head of Clinical Operations



Thomas Parr

Chief Scientific Officer



Timothy Keutzer

Senior VP of Development



Troy Lister

VP of Research



Further reading

Title
Author
Link
Type

Spero Therapeutics Announces Positive Results from SPR720 IND-Enabling Studies and Plans to Initiate a Phase 1 Trial

Spero Therapeutics, Inc.

Web

Spero Therapeutics Receives QIDP Designation from the U.S. FDA for the Development of SPR720

Spero Therapeutics, Inc.

Web

Documentaries, videos and podcasts

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Date
Link





Companies

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References