SHERLOCK (nucleic acid detection)

SHERLOCK (nucleic acid detection)

SHERLOCK (Specific High Sensitivity Enzymatic Reporter UnLOCKing) is a nucleic acid detection system based on CRISPR-Cas13a that can detect viruses, distinguish pathogenic bacteria, genotype human DNA and cell-free tumor DNA mutations.

Edit ID  8755622 

Dawson Sewell
Dawson Sewell approved a suggestion from Golden's AI on 13 December, 2018 5:17 pm
Edits made to:
Article (+15/-15 characters)

Article

The SHERLOCK system was developed by a team lead by Feng Zhang, assistant professor at the Broad InstituteBroad Institute at MIT and Harvard described in Science in 2017. Collaborator Pardis Sabeti, a geneticist-virologist and professor at Harvard University, lead research published in 2018, which demonstrated the feasibility of using SHERLOCK for detecting Zika virus and dengue virus in field conditions, instrument-free, in patient body fluids (urine and saliva) at concentrations of 1 copy per microliter.SHERLOCK can quantify the amount of virus or cancer mutation in the sample. SHERLOCK can quickly be adapted to target new virus mutations when they arise.

Golden logo
Text is available under the Creative Commons Attribution-ShareAlike 4.0; additional terms apply. By using this site, you agree to our Terms & Conditions.