SHERLOCK (nucleic acid detection)

SHERLOCK (nucleic acid detection)

SHERLOCK (Specific High Sensitivity Enzymatic Reporter UnLOCKing) is a nucleic acid detection system based on CRISPR-Cas13a that can detect viruses, distinguish pathogenic bacteria, genotype human DNA and cell-free tumor DNA mutations.

Edit ID  8755594 

Dawson Sewell
Dawson Sewell approved a suggestion from Golden's AI on 13 December, 2018 5:16 pm
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The SHERLOCK system was developed by a team lead by Feng Zhang, assistant professor at the Broad Institute at MIT and Harvard described in Science in 2017. Collaborator Pardis SabetiPardis Sabeti, a geneticist-virologist and professor at Harvard University, lead research published in 2018, which demonstrated the feasibility of using SHERLOCK for detecting Zika virus and dengue virus in field conditions, instrument-free, in patient body fluids (urine and saliva) at concentrations of 1 copy per microliter.SHERLOCK can quantify the amount of virus or cancer mutation in the sample. SHERLOCK can quickly be adapted to target new virus mutations when they arise.

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