Rheostat is a biotechnology company developing treatments for neurodegenerative disease by modulation of mitophagy and autophagy that is headquartered in Cambridge, Massachusetts and was founded in 2018 by Tim Harris, Wade Harper, Bert Vallee, and Natalie Vallee.
Rheostat is focusing on molecular pathways involved in clearance of toxic components such as damaged organelles or aggregated proteins because mutations in these pathways cause many neurodegenerative diseases associated with cognitive impairment. Rheostat aims to use knowledge about these clearance pathways to find and develop small molecules that can restore cellular balance for the treatment of neurodegenerative and rare diseases.
Funding
Series A
On November 26, 2018 Rheostat Therapeutics completed their series A funding round with $23 million in funding from MRL Ventures Fund (lead investor), AbbVie Biotech Ventures, SV Health Investors, Dementia Discovery Fund, Amgen Ventures, Alexandria Venture Investments, and the Dementia Discovery Fund.
Timeline
People
Christophe J. Echeverri
Interim Head of Operations
Darby R. Schmidt
Senior Director, Head of Chemistry
J. Stefan Kaczmarek
Scientific Director
Joshua Resnick
Chair and CEO
Magdalene Moran
Principle Investigator
Nathaniel Tyler Blair
Associate Director of Biology
Further reading
Documentaries, videos and podcasts
Companies
References
Rheostat Therapeutics
Company
Therapeutics
Neuroscience
Cambridge, Massachusetts
Related Topics
Parkinson's diseaseA synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.
DementiaBroad category of brain diseases that cause a long term and often gradual decrease in the ability to think and remember that is great enough to affect a person's daily functioning
BiotechnologyBiolotechnology can refer to the application of science and technology to living organisms or the use of living organisms, their parts, products or models thereof to solve a problem, produce knowledge or produce goods and services. Biotechnology may involve the alteration of living or non-living materials.
Contributors
- 1
Dawson Sewell
Seeking to explain science and technology through simple writing. - 2
Meredith Hanel
Medical Genetics PhD, following life science applications that improve the health of humans and our planet. - 3
Carla Faraguna
Golden People and Operations. - 4
Jude Gomila
Founder and CEO of Golden, Entrepreneur. Previously Co Founder of Heyzap. Investor in 100+ companies. Cantabrigian (Gonville and Caius).
