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Rheostat Therapeutics

Rheostat Therapeutics

Rheostat, located at 300 Technology Square, in Cambridge, Massachusetts is a biotech company developing treatments for neurodegenerative diseases by targeting mitophagy and autophagy pathways.

Rheostat is a biotechnology company developing treatments for neurodegenerative disease by modulation of mitophagy and autophagy that is headquartered in Cambridge, Massachusetts and was founded in 2018 by Tim Harris, Wade Harper, Ivan Dikic and Josh Resnick. 



Rheostat is focusing on molecular pathways involved in clearance of toxic components such as damaged organelles or aggregated proteins because mutations in these pathways cause many neurodegenerative diseases associated with cognitive impairment. Rheostat aims to use knowledge about these clearance pathways to find and develop small molecules that can restore cellular balance for the treatment of neurodegenerative and rare diseases. 

Funding

Series A

On November 26, 2018 Rheostat Therapeutics completed their series A funding round with $23 million in funding from MRL Ventures Fund (lead investor), AbbVie Biotech Ventures, SV Health Investors, Dementia Discovery Fund, Amgen Ventures, Alexandria Venture Investments, and the Dementia Discovery Fund. 

Timeline

Funding rounds

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People

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Role
LinkedIn

Cristina Csimma

Executive Chair



Darby R. Schmidt

Senior Director, Head of Chemistry



Donato del Camino

Senior Director



J. Stefan Kaczmarek

Senior Director



Joshua Resnick

Board Chair



Magdalene Moran

President and Chief Scientific Officer



Nathaniel Blair

Associate Director of Biology



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