Prokarium's stated vision is that all protein vaccines can be delivered orally. Prokarium is based in Keele and London, UK.The firm has developed a proprietary synthetic biology platform, Vaxonella, that enables thermostable microbes to be taken orally, to then produce vaccines from inside the body's own immune cells. Vaxonella has 12-week thermostability at 400C. The only other known vaccine to remain stable at this temperature is the meningitis A vaccine MenAfriVac, but only for up to four days.
In February 2018 , Prokarium completed an investment round, raising $10 million for the clinical development of vaccines against chlamydia, C.difficile and enteric fever, in addition to an expansion for the immune-oncology R&D team. This financing round was led by Riyadh Valley Company, followed by Prokarium's original investor Flerie Invest as well as Korea Investment Partners.
Prokarium's development pipeline also includes a vaccine against plague, being taken into a phase 1 clinical trial under a SBRI contract funded by the UK Department of Health and Social Care and managed by Innovate UK, paving the way for new biodefence and epidemic preparedness applications.
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