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Oxford Nanopore Technologies

Oxford Nanopore Technologies

DNA sequencing company specializing in rapid long-read sequencing through nanopores.

All edits by  Isaac Larkin 

Edits on 20 Jun 2019
Isaac Larkin"I've learned from public ONT talks that the membrane they embed the pore in is not a traditional phospholipid bilayer"
Isaac Larkin edited on 20 Jun 2019 8:46 pm
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Oxford Nanopore Technologies (also known as Oxford Nanopore) is a British biotechnology company that produces machines and kits for nanopore sequencing of both DNA and RNA. Oxford Nanopore's sequencing technology is based on measuring the voltage across a lipid membrane as a motor protein threads a single strand of nucleic acid through a transmembrane protein pore. This approach to reading DNA enables Oxford Nanopore to build small, low-power, inexpensive DNA sequencers; to sequence extremely long strands of DNA; and to perform rapid DNA sequence detection and analysis. These characteristics have lead to the use of Oxford Nanopore devices to perform genetic analysis in remote or extreme environments, such as deep in a rainforest or on the International Space Station; and to their use for rapid detection, diagnosis and analysis of pathogens in the field, such as during the 2014-15 Ebola outbreak in West Africa.

Edits on 13 Jun 2018
Isaac Larkin"Clarified that ONT can sequence both DNA and RNA"
Isaac Larkin edited on 13 Jun 2018 9:57 pm
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Article (+26/-10 characters)

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Oxford Nanopore Technologies is a British biotechnology company that produces machines and kits for nanopore sequencing of both DNA sequencingand RNA. Oxford Nanopore's sequencing technology is based on measuring the voltage across a lipid membrane as a motor protein threads a single strand of nucleic acid through a transmembrane protein pore. This approach to reading DNA enables Oxford Nanopore to build small, low-power, inexpensive DNA sequencers; to sequence extremely long strands of DNA; and to perform rapid DNA sequence detection and analysis. These characteristics have lead to the use of Oxford Nanopore devices to perform genetic analysis in remote or extreme environments, such as deep in a rainforest or on the International Space Station; and to their use for rapid detection, diagnosis and analysis of pathogens in the field, such as during the 2014-15 Ebola outbreak in West Africa.

Isaac Larkin
Isaac Larkin edited on 13 Jun 2018 9:54 pm
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Article (-32 characters)

Article

Oxford Nanopore Technologies is a British biotechnology company that produces machines and kits for nanopore DNA sequencing. The stated goal of the company Oxford Nanopore's sequencing technology is based on measuring the voltage across a lipid membrane as a motor protein threads a single strand of nucleic acid through a transmembrane protein pore. This approach to reading DNA enables Oxford Nanopore to build small, low-power, inexpensive DNA sequencers; to sequence extremely long strands of DNA; and to perform rapid DNA sequence detection and analysis. These characteristics have lead to the use of Oxford Nanopore devices to perform genetic analysis in remote or extreme environments, such as deep in a rainforest or on the International Space Station; and to their use for rapid detection, diagnosis and analysis of pathogens in the field, such as during the 2014-15 Ebola outbreak in West Africa.

Isaac Larkin"Creating an MVP for ONT"
Isaac Larkin edited on 13 Jun 2018 9:53 pm
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Oxford Nanopore Technologies

DNA sequencing company specializing in rapid long-read sequencing through nanopores, whose stated goal is to enable 'anyone, to sequence anything, anywhere.'

Article

Oxford Nanopore Technologies is a British biotechnology company that produces machines and kits for nanopore DNA sequencing. The stated goal of the company Oxford Nanopore's sequencing technology is based on measuring the voltage across a lipid membrane as a motor protein threads a single strand of nucleic acid through a transmembrane protein pore. This approach to reading DNA enables Oxford Nanopore to build small, low-power, inexpensive DNA sequencers; to sequence extremely long strands of DNA; and to perform rapid DNA sequence detection and analysis. These characteristics have lead to the use of Oxford Nanopore devices to perform genetic analysis in remote or extreme environments, such as deep in a rainforest or on the International Space Station; and to their use for rapid detection, diagnosis and analysis of pathogens in the field, such as during the 2014-15 Ebola outbreak in West Africa.

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While the basecalling accuracy of Oxford Nanopore sequencers remains lower than those achievable by Sanger or Illumina sequencing, both per-read and consensus assembly accuracy have rapidly improved in the past few years.

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