Oxford Nanopore Technologies (also known as Oxford Nanopore) is a British biotechnology company that produces machines and kits for nanopore sequencing of both DNA and RNA. Oxford Nanopore's sequencing technology is based on measuring the voltage across a lipid membrane as a motor protein threads a single strand of nucleic acid through a transmembrane protein pore. This approach to reading DNA enables Oxford Nanopore to build small, low-power, inexpensive DNA sequencers; to sequence extremely long strands of DNA; and to perform rapid DNA sequence detection and analysis. These characteristics have lead to the use of Oxford Nanopore devices to perform genetic analysis in remote or extreme environments, such as deep in a rainforest or on the International Space Station; and to their use for rapid detection, diagnosis and analysis of pathogens in the field, such as during the 2014-15 Ebola outbreak in West Africa.
While the basecalling accuracy of Oxford Nanopore sequencers remains lower than those achievable by Sanger or Illumina sequencing, both per-read and consensus assembly accuracy have rapidly improved in the past few years.
Oxford Nanopore has stated its goal to enable 'anyone, to sequence anything, anywhere.'
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- DNA sequencingThe process of determining the precise order of nucleotides within a DNA molecule.
- Nanopore sequencing
- RNARNA stands for ribonucleic acid. Messenger RNA (mRNA) is copied or transcribed from DNA and carries the coding information for the generation of a protein encoded by a gene. Different types of non-coding RNAs have roles in converting mRNA into protein and perform other regulatory functions in the cell.