The field of nanotherapeutics is the application of nanotechnology to medicine and drug development.
Nanocrystals are generally producesproduced used two approaches. The first approach includes top-down methods, where large particles are broken down into a smaller size, like media milling (pearl milling) and high-pressure homogenization (HPH). Milling pearls, usually made of stainless steel, glass, zirconium oxide or highly cross-linked polystyrene resin, are put into a milling chamber with stabilizer, drug and dispersion media. HPH methods use sonicators, homogenizers, mortar and pestle or jet mills, to create micronized suspensions, followed by exposure to collisions, strong cavitation and high shear forces by passing through a narrow gap.