A field of research that explores the modeling and building of “self-architecturing” systems and focuses on the programmability and controllability of self-assembling agents. The field models self-organization in biological systems with a view to export their self-formation capabilities to engineered systems.
Induction of the GATA6GATA6 transcription factor has resulted in formation of the three human germ layers, symmetry breaking and triggered differentiation of endoderm and mesoderm tissue types. GATA6-engineered cells self-organize and self-produce signaling cues for tissue morphogenesis. Synthetic biology approaches could be used to design gene circuits with specific features to induce certain tissue types such and perhaps induce angiogenesis or innervation into organoids.
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