GoldenGolden
Advanced Search
Long non-coding RNA (lncRNA)

Long non-coding RNA (lncRNA)

Non-protein coding transcripts longer than 200 nucleotides.

All edits

Edits on 2 Mar, 2020
Golden AI"Attach Wikidata entity ID"
Golden AI edited on 2 Mar, 2020
Edits made to:
Infobox (+1 properties)
Infobox
Wikidata entity ID
Q15087973
Edits on 12 Aug, 2019
Will Suter
Will Suter approved a suggestion from Golden's AI on 12 Aug, 2019
Edits made to:
Article (+3/-3 characters)
Article

lncRNAs have roles in diverse molecular mechanisms including epigenetic regulation, (post-)transcriptional gene regulation and compartmentalization. Most lncRNAs carry out their functions by binding to RNA-binging proteins such as transcription factors, chromatin modifiers and scaffolding proteins. Most lncRNAs bind to ribonucleoproteins (RNPs) and modulate their functions. Other LncRNAs bind to miRNAs and inhibit their interference on the expression of a third target. LncRNAs can also bind to DNADNA targets and attract chromatin modifier proteins, creating RNA-DNA-protein complexes in nuclear domains. LncRNAs can elicit a specific activity by controlling the localization, interaction and availability of effectors that regulate biological activity.

Edits on 11 Aug, 2019
Stijn de Vries
Stijn de Vries approved a suggestion from Golden's AI on 11 Aug, 2019
Edits made to:
Article (+15/-15 characters)
Article

Enhancer: The lncRNA interacts with both the promoter an enhancer of a gene and creates chromosomal looping which brings the regions together to stimulate gene expressiongene expression

Stijn de Vries
Stijn de Vries approved a suggestion from Golden's AI on 11 Aug, 2019
Edits made to:
Article (+3/-3 characters)
Article

Unlike protein-coded genes where the RNARNA transcript is an intermediate that is translated into a protein, non-coding RNAs (ncRNAs) function as an RNA. ncRNAs are divided into two classes based on length. Small non-coding RNAs include miRNAs, tRNAs and small nucleolar RNAs and the other class are long non-coding RNAs (lncRNAs). According to the 2019 version of the GENCODE project the human genome contains 19940 protein-coding genes, 16066 lncRNA genes and 7577 short ncRNA genes, of which 1881 are miRNAs. LncRNAs are defined as transcripts longer than 200 nt which have no protein coding potential. LncRNAs can be classified based on genomic localization and orientation, subcellular localization and mechanism of action.

Edits on 9 Aug, 2019
Meredith Hanel
Meredith Hanel edited on 9 Aug, 2019
Edits made to:
Table (+1 rows) (+3 cells) (+167 characters)
Table

Title
Author
Link
Type
Date

Long Non-coding RNAs: At the Heart of Cardiac Dysfunction?

Lisa Hobuß1, Christian Bär1 and Thomas Thum

Meredith Hanel
Meredith Hanel edited on 9 Aug, 2019
Edits made to:
Topic thumbnail

Long non-coding RNA (lncRNA)

Non-protein coding transcripts longer than 200 nucleotides.

Meredith Hanel
Meredith Hanel edited on 9 Aug, 2019
Edits made to:
Article (+223/-2 characters)
Article

lncRNAs are proposed as targets for interventional therapy in cardiovascular aging because of their emerging role in cardiac aging and disease. Developmental enhancer-associated lncRNAs have been shown to be reexpressed in stressed mouse and human hearts, which is potentially part of a reactivation of fetal gene program that occurs under pathological conditions.

Edits on 8 Aug, 2019
Meredith Hanel
Meredith Hanel edited on 8 Aug, 2019
Edits made to:
Description (+1/-14 characters)
Article (+2878 characters)
Topic thumbnail

Long non-coding RNA Long non-coding RNA (lncRNA)

Non-protein coding transcripts longer than 200 nucleotides (perkel 2013).

Article

Unlike protein-coded genes where the RNA transcript is an intermediate that is translated into a protein, non-coding RNAs (ncRNAs) function as an RNA. ncRNAs are divided into two classes based on length. Small non-coding RNAs include miRNAs, tRNAs and small nucleolar RNAs and the other class are long non-coding RNAs (lncRNAs). According to the 2019 version of the GENCODE project the human genome contains 19940 protein-coding genes, 16066 lncRNA genes and 7577 short ncRNA genes, of which 1881 are miRNAs. LncRNAs are defined as transcripts longer than 200 nt which have no protein coding potential. LncRNAs can be classified based on genomic localization and orientation, subcellular localization and mechanism of action.

lncRNAs have roles in diverse molecular mechanisms including epigenetic regulation, (post-)transcriptional gene regulation and compartmentalization. Most lncRNAs carry out their functions by binding to RNA-binging proteins such as transcription factors, chromatin modifiers and scaffolding proteins. Most lncRNAs bind to ribonucleoproteins (RNPs) and modulate their functions. Other LncRNAs bind to miRNAs and inhibit their interference on the expression of a third target. LncRNAs can also bind to DNA targets and attract chromatin modifier proteins, creating RNA-DNA-protein complexes in nuclear domains. LncRNAs can elicit a specific activity by controlling the localization, interaction and availability of effectors that regulate biological activity.

lncRNAs are classified into five groups based on their mechanism of action in a 2019 review in Journal of Molecular Cell Biology by Lozano-Vidal, Bink and Boon:

Signal: The expression of lncRNA is regulated in response to a stimulus, at a certain developmental time or in a specific cell type, which helps to integrate the response to the cellular context for quick regulatory changes.

Decoy: The lncRNA binds to an RNA-binding protein, RNA molecule, transcription factor or regulatory effector and inhibits its biological function by sequestering it. This group would include LncRNAs acting as miRNA sponges with the suggested term competitive endogenous RNAs (ceRNAs)

Guide: The lncRNA binds to a transcription factor or chromatin modifier and brings it to the target promoter to alter the expression of a certain gene. This mechanism can work on neighbouring genes (in cis) or on distant genes (in trans).

Scaffold: Distinct domains on the lncRNA bind several RNA-binding proteins and bring them together so they interact in macromolecular complexes.

Enhancer: The lncRNA interacts with both the promoter an enhancer of a gene and creates chromosomal looping which brings the regions together to stimulate gene expression

Cardiac aging and disease

lncRNAs are proposed as targets for interventional therapy in cardiovascular aging because of their emerging role in cardiac aging and disease.

Edits on 1 Jan, 2017
Golden AI"Initial topic creation"
Golden AI created this topic on 1 Jan, 2017
Edits made to:
Description (+72 characters)
Article
Topic thumbnail

 Long non-coding RNA

Non-protein coding transcripts longer than 200 nucleotides (perkel 2013)

Golden logo
Text is available under the Creative Commons Attribution-ShareAlike 4.0; additional terms apply. By using this site, you agree to our Terms & Conditions.