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Leucadia Therapeutics

Leucadia Therapeutics

Leucadia Therapeutics is a company working on Alzheimer's Disease.

Leucadia is is a biotechnology company focused on curing Alzheimer’s disease that is headquartered in Los Angeles, California and was founded in 2015 by Doug Ethell. 



The company is using a trigger for Alzheimer’s disease pathology around which they have developed a patented strategy for correcting the condition. Their research points to plaques and tangles as the effect of a more serious underlying condition which triggers those pathological features. Leucadia’s Arethusta technology is based on the idea of improving cerebrospinal fluid (CSF) clearance of metabolites from intercellular spaces in the brain. Aging and events during life can occlude the cribiform plate, a porous bone where CSF drains across, and reduce CSF-mediated clearance of toxic metabolites. Arethusta restores CSF flow across the cribiform plate. 



The name of the treatment device, Arethusa, is based on the water nymph from Greek mythology who was saved by Artemis by turning her into a hidden underground stream. By analogy, Leucadia’s device will create an under-the-tissue channel to drain fluid from the brain. The Arethusta device will be introduced through the nose as the cribriform plate is at the top of the nasal cavity.



Founding investors include the Methuselah Foundation and the Methuselah Fund. 

Funding

Seed

On December 8, 2017 Leucadia Therapeutics completed their seed funding round with an undisclosed amount of funding from the Methuselah Foundation. 

Timeline

People

Name
Role
LinkedIn

David Gobel

Senior Advisor



Doug Ethell

Founder, CEO



Further reading

Title
Author
Link
Type
Date

Undoing Aging: Doug Ethell's Presentation on the Leucadia Therapeutics Approach to Treating Alzheimer's Disease

Reason

Web



What If Alzheimer's Disease Is Caused by "Bad Plumbing"?

Methuselah

Web



Documentaries, videos and podcasts

Title
Date
Link

Doug Ethell at Undoing Aging 2018

July 18, 2018

Companies

Company
CEO
Location
Products/Services









References