The kinase enzyme catalyses the transfer of the terminal phosphate group of ATP to the hydroxyl moiety in the amino acid residue. Phosphatases are enzymes which remove a phosphate group from a protein. These two enzymatic processes control protein activities in the cell and are involved in functions like responding to external stimuli. Kinases turn on protein function on and phosphatases turn proteins off. Most kinases promote cell proliferation, survival and migration when active or overexpressed and their malfunction is associated with cancer. Inherited mutations in kinases are associated with cancer.
There are 538 kinases encoded in the human genome. The kinome of an organism is the complete set of protein kinases encoded by the genome. Since many kinases are associated with human cancer, they have become the second most targeted group of for cancer drugs. Synthetic and natural kinase inhibitors are therapeutic strategies for treating malignancies.
In the field of synthetic biology phosphorylation circuits have been engineered using phosphor-regulon motifs that act as biological switches which can change cell fate in yeast. Opto-kinases are optogenetics tools that allow the activation of inhibition of proteins kinases with light.
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- NovartisNovartis is a healthcare and pharmaceutical company based in Basel, Switzerland, incorporated in 1996.
- PhosphorylationThe process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. Protein phosphorylation is the main molecular mechanism by which cells regulate protein function in response to extracellular stimuli.