Indee Labs

Indee Labs was founded in August 2015 with a 'mission"mission to democratize gene-modified cell therapies'," such as chimeric antigen receptor T cells (CAR-T). The team is developing a novel transfection technology that can rapidly and efficiently deliver a variety of genetic material (e.g., DNA, RNA, protein, and/or various complexes) to human primary immune cells in seconds.

The core technology, microfluidic vortex shedding (μVS), uses a microscopic fluid dynamics phenomenon based on vortex shedding to hydrodynamically porate the cell membrane, allowing for the deliberate introduction of genetic material to human primary immune cells. Vortex shedding is not a new phenomenon. It can be observed as water flows past boulders in rivers while also being seen as clouds drift over mountains.

μVS is not the only transfection technology,; however, it is shown to be able to rapidly deliver a range of genetic material to human primary immune cells with high cell recovery, high cell viability and, high efficiency, and high throughput. Furthermore, μVS results in negligible perturbation of immune cell proliferation, activation, exhaustion, phenotype, function, norand transcriptome-wide gene expression. μVS is also induced with a 5 mm x 10 mm microfluidic device manufactured using industry-standard semiconductor processes. Cumulatively, this means μVS is an extremely scalable, gentle, and robust alternative to incumbent technologies, such as viral transduction and electroporation.

As of May 2018, Indee Labs had accumulated more than USD$6.1 million dollars in angel, venture, and non-dilutive capital.