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HIV

HIV

Human immunodeficiency virus (HIV) is a type of retrovirus, that if left untreated can lead to AIDs (Acquired ImmunoDeficiency Syndrome.

Human immunodeficiency virus (HIV) is a type of retrovirus, that if left untreated can lead to AIDs (acquired immunodeficiency syndrome). 

Timeline

September 11, 2019

CRISPR-Edited Stem Cells in a Patient with HIV and Acute Lymphocytic Leukemia

Researchers based in China used CRISPR to edit hematopoietic stem and progenitor cells (HSPCs) to make the gene CCR5 non-functional, which makes cells resistant to HIV-1. The CRISPR-edited CCR5-ablated HSPCs were transplanted into a patient with HIV-1 infection and acute lymphoblastic leukemia, which was in remission. Although there was long-term engraftment of the edited HSPCs, only about 5% of lymphocytes contained the CCR5 disruption.

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