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Favipiravir

Favipiravir

An anti-viral drug capable of inhibiting the RNA-dependent RNA polymerase (RdRp) of RNA viruses.

Favipiravir is an anti-viral drug capable of inhibiting the RNA-dependent RNA polymerase (RdRp) of RNA viruses. The official chemical name of Favipiravir is T-705; 6-fluoro-3-hydroxy-2-pyrazinecarboxamide. It was discovered by Toyama Chemical Co., Ltd during experiments held by the company for finding chemical compounds capable of exhibiting anti-viral activity against influenza viruses.

Anti-viral activity

Favipiravir must undergo phosphoribosylation inside of cells (intracellular) to become it's active form called favipiravir-RTP (favipiravir ribofuranosyl-5'-triphosphate). Research suggests Favipiravir exhibits a broad spectrum of anti-viral activity towards RNA viruses due to it's mechanism of action, and is effective for treating a wide range of types and sub-types of RNA influenza viruses, including strains typically showing resistance to anti-influenza drugs, which include: arenaviruses, bunyaviruses and filoviruses.

Mechanism of action

Favipiravir-RTP (the active form of Favipiravir) is able to become incorporated in viral RNA (vRNA), and may act as a binding agent on vRNA conserved polymerase domains which prevents the ability of vRNA to use the cellular machinery of its host organism required for its own replication and transcription. This mechanism of action is what is thought to give Favipiravir its anti-viral properties.

Timeline

Further Resources

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News

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Staff Writer
May 24, 2021
mint
Favipiravir is often used to treat patients with mild to moderate Covid-19 symptoms.BALflu has the efficacy to clear the virus faster by 28.7% and is marketed at a very affordable price of ₹85 per tablet
May 11, 2021
The Times of India
India Business News: Call it the Covid effect. Anti-viral drug Favipiravir, used for Covid-19 treatment, has rocketed to the rank of the largest-selling pharma brand in Ap
May 5, 2021
Hindustan Times
The countries have been aiding India by sending oxygen concentrators, oxygen cylinders, ventilators, vials of anti-malarial drug Remdesivir and strips of Favipiravir among other critical equipment.
Aparna Banerjea
May 4, 2021
mint
The firm has successfully developed the active pharmaceutical ingredient (API) and the formulation for Favipiravir through its own in-house R&D team.The drug will be available as a prescription-based medication, with recommended doses
April 2, 2021
clinicaltrials.gov
Efficacy and Safety of Favipiravir and Ribavirin Formulation for Treatment of COVID-19 - Full Text View.
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References

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