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Epigenetic CRISPR/Cas9

Epigenetic CRISPR/Cas9

Gene editing technology

Epigenetic CRISPR/Cas9 is a modified form of the gene editing technology CRISPR, designed to activate genes without cutting DNA by adding or removing methyl groups in specific positions.

This technique allows researchers to see how changes affect gene expression and has been tested in cultured mouse cells and live mice.

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Hsin-Kai Liao7, Fumiyuki Hatanaka7, Toshikazu Araoka7, Pradeep Reddy, Min-Zu Wu, Yinghui Sui, Takayoshi Yamauchi, Masahiro Sakurai, David D. O’Keefe, Estrella Núñez-Delicado, Pedro Guillen, Josep M. Campistol, Cheng-Jang Wu, Li-Fan Lu, Concepcion Rodriguez Esteban, Juan Carlos Izpisua Belmonte

In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation

Academic paper

Jussi Taipale, Sandeep Botla, Emma Haapaniemi, Bernhard Schmierer, Jenna Persson

CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response

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