Epigenetic CRISPR/Cas9 is a modified form of the gene editing technology CRISPR, designed to activate genes without cutting DNA by adding or removing methyl groups in specific positions.
This technique allows researchers to see how changes affect gene expression and has been tested in cultured mouse cells and live mice.
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Hsin-Kai Liao7, Fumiyuki Hatanaka7, Toshikazu Araoka7, Pradeep Reddy, Min-Zu Wu, Yinghui Sui, Takayoshi Yamauchi, Masahiro Sakurai, David D. O’Keefe, Estrella Núñez-Delicado, Pedro Guillen, Josep M. Campistol, Cheng-Jang Wu, Li-Fan Lu, Concepcion Rodriguez Esteban, Juan Carlos Izpisua Belmonte
In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation
Jussi Taipale, Sandeep Botla, Emma Haapaniemi, Bernhard Schmierer, Jenna Persson
CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response
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- CRISPRClustered regularly interspaced short palindromic repeats (CRISPR) is a prokaryotic adaptive immune response that provides immunity against foreign nucleic acids, such as viral DNA and bacterial plasmids, through the use of crRNAs (CRISPR RNAs) and associated Cas genes.
- Cas9Microbial protein found in streptococcus pyogenes m1 gas
- Salk Institute for Biological StudiesLife sciences research institute