Chloroquine

Chloroquine

Chemical compound and drug used to treat malaria, autoimmune disease and other conditions

All edits by  Meredith Hanel 

Edits on 6 April, 2020
Meredith Hanel
Meredith Hanel edited on 6 April, 2020 8:47 pm
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A randomized controlled trial conducted by researchers at Wuhan University includedincluding 62 patients and found that time to clinical recovery, based on clinical characteristics and radiological results 5 days after treatment, was significantly shortened in the hydroxychloroquine group.

Meredith Hanel
Meredith Hanel edited on 6 April, 2020 8:40 pm
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As of March 26, 2020 the NIH Clinical Trials database showed 18 clinical trials listing hydroxychloroquine as an intervention. Hydroxychloroquine alone and in combination with the the antibiotic azithromycin (aka Zithromas or Azithrocin) have reported early evidence of being effective in treating COVID-19 in preliminary results in a small study on 30 patients in France, led by Didier Raoult. Controls in the study were patients who refused treatment, had exclusion criteria and patients in other medical centers that did not receive hydroxychloroquine. According to the paper Azithromycin was given to some patients to prevent bacterial super-infection. Azithromycin is also known to have immunomodulatory effects.It is not clear if differences between patients that received hydroxychoroquine alone and the combination therapy may be due to differences in the patient's viral load between the two groups. Subsequent results from Raoult's group have been released where all patients were given the hydroxychloroquine and azithromycin combination.

...

A randomized controlled trial conducted by researchers at Wuhan University included 62 patients and found that time to clinical recovery, based on clinical characteristics and radiological results 5 days after treatment, was significantly shortened in the hydroxychloroquine group.

Meredith Hanel
Meredith Hanel edited on 6 April, 2020 8:01 pm
Edits made to:
Article (+39/-132 characters)
Article

As of March 26, 2020 the NIH Clinical Trials database showed 18 clinical trials listing hydroxychloroquine as an intervention. Hydroxychloroquine alone and in combination with the the antibiotic azithromycin (aka Zithromas or Azithrocin) have reported early evidence of being effective in treating COVID-19 in preliminary results in a small study on 30 patients in France, led by Didier Raoult. The trial lacks a control group that did not receive hydroxychloroquine. According to the paper Azithromycin was given to some patients to prevent bacterial super-infection. Azithromycin is also known to have immunomodulatory effects.It is not clear if differences between patients that received hydroxychoroquine alone and the combination therapy may be due to differences in the patient's viral load between the two groups. Subsequent results from Raoult's group have been released where all patients were given the hydroxychloroquine and azithromycin combination.

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TheA firstrandomized controlled study, a randomized trial comparing patients treated with hydroxychloroquine and a control group with 30 patients performed by researchers at Fudan University, Shanghai. This study led by LU Hongzhou found no difference between the hydroxychloroquine and control groups in the time it took to achieve negative throat swabs for the virus and normalization of body temperature and radiological progression by CT imaging. The authors noted that a larger sample size was needed to assess the effects of hydroxychloroquine on COVID-19.

Edits on 2 April, 2020
Meredith Hanel
Meredith Hanel edited on 2 April, 2020 1:27 pm
Edits made to:
Article (+830/-10 characters)
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Chloroquine has been reported to be an effective antiviral therapeutic against COVID-19 in treatments done in China and South Korea, with clinical trialtrials ongoing as of March 2020. Treatment with chloroquine tablets was reported to show favorable outcomes such as faster time to recover and shorter hospital stay in people with COVID-19 infections. Laboratory research from the US CDC shows chloroquine also has potential to treat prophylactically. Chloroquine is being investigated to treat COVID-19 in the form of chloroquine phosphate or hydroxychloroquine sulfate which are sometimes referred to as chloroquine and hydroxychloroquine respectively.

...

As of March 26, 2020 the NIH Clinical Trials database showed 18 clinical trials listing hydroxychloroquine as an intervention. Hydroxychloroquine alone and in combination with the the antibiotic azithromycin (aka Zithromas or Azithrocin) have shownreported early evidence of being effective in treating COVID-19 in preliminary results in a small study on 30 patients in France, led by Didier Raoult. The trial lacks a control group that did not receive hydroxychloroquine. According to the paper Azithromycin was given to some patients to prevent bacterial super-infection. Azithromycin is also known to have immunomodulatory effects.It is not clear if differences between patients that received hydroxychoroquine alone and the combination therapy may be due to differences in the patient's viral load between the two groups. Subsequent results from Raoult's group have been released where all patients were given hydroxychloroquine and azithromycin.

The first controlled study, a randomized trial comparing patients treated with hydroxychloroquine and a control group with 30 patients performed by researchers at Fudan University, Shanghai. This study led by LU Hongzhou found no difference between the hydroxychloroquine and control groups in time to achieve negative throat swabs for the virus and normalization of body temperature and radiological progression by CT imaging. The authors noted that a larger sample size was needed to assess the effects of hydroxychloroquine on COVID-19.

Mechanism for antiviral activity

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Edits on 26 March, 2020
Meredith Hanel
Meredith Hanel edited on 26 March, 2020 8:38 pm
Edits made to:
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Article

As of March 26, 2020 the NIH Clinical Trials database showed 18 clinical trials listing hydroxychloroquine as an intervention. Hydroxychloroquine alone and in combination with the the antibiotic azithromycin (aka Zithromas or Azithrocin) have shown early evidence of being effective in treating COVID-19 in preliminary results in a small study on 30 patients in France. Azithromycin was given to some patients to prevent bacterial super-infection. At this time thereAzithromycin is noalso otherknown datato onhave useimmunomodulatory ofeffects.It azithromycinis onnot coronavirusesclear andif differences between patients that received hydroxychoroquine alone and the combination therapy may be due to differences in the patient's viral load between the two groups.

Meredith Hanel
Meredith Hanel edited on 26 March, 2020 3:16 pm
Edits made to:
Article (+78 characters)
Article

As of March 26, 2020 the NIH Clinical Trials database showed 18 clinical trials listing hydroxychloroquine as an intervention. Hydroxychloroquine alone and in combination with the antibiotic azithromycin (aka Zithromas or Azithrocin) have shown early evidence of being effective in treating COVID-19 in preliminary results in a small study on 30 patients in France. Azithromycin was given to some patients to prevent bacterial super-infection. At this time there is no other data on use of azithromycin on coronaviruses and differences between patients that received hydroxychoroquine alone and the combination therapy may be due to differences in the patient's viral load between the two groups.

Meredith Hanel
Meredith Hanel edited on 26 March, 2020 3:02 pm
Edits made to:
Article (+281/-80 characters)
Article

As of March 26, 2020 the NIH Clinical Trials database showed 18 clinical trials listing hydroxychloroquine as an intervention. AHydroxychloroquine alone and in combination of hydroxychloroquine andwith the antibiotic azithromycin (aka Zithromas or Azithrocin) have shown early evidence of being effective in treating COVID-19 in preliminary results in a small study on 30 patients in France. HydroxychloroquineAt wasthis effectivetime there is no other data on ituse ownof butazithromycin noton ascoronaviruses effectiveand asdifferences between patients that received hydroxychoroquine alone and the combination therapy may be due to differences in the patient's viral load between the two groups.

Edits on 26 March, 2020
Meredith Hanel
Meredith Hanel edited on 26 March, 2020 2:37 pm
Edits made to:
Article (+417/-126 characters)
Article

Chloroquine has been reported to be an effective antiviral therapeutic against COVID-19 in treatments done in China and South Korea, with clinical trial ongoing as of March 2020. Treatment with chloroquine tablets was reported to show favorable outcomes such as faster time to recover and shorter hospital stay in people with COVID-19 infections. Laboratory research from the US CDC shows chloroquine also has potential to treat prophylactically. Chloroquine is being investigated to treat COVID-19 in the form of chloroquine phosphate or hydroxychloroquine sulfate which are sometimes referred to as chloroquine and hydroxychloroquine respectively. As of March 26, 2020 the NIH Clinical Trials database showed 18 clinical trials listing hydroxychloroquine as an intervention.

As of March 26, 2020 the NIH Clinical Trials database showed 18 clinical trials listing hydroxychloroquine as an intervention. A combination of hydroxychloroquine and the antibiotic azithromycin (aka Zithromas or Azithrocin) have shown early evidence of being effective in treating COVID-19 in a small study on 30 patients in France. Hydroxychloroquine was effective on it own but not as effective as the combination.

Meredith Hanel
Meredith Hanel edited on 26 March, 2020 2:25 pm
Edits made to:
Timeline (+2 events) (+222 characters)
Article (+127 characters)
Article

Chloroquine has been reported to be an effective antiviral therapeutic against COVID-19 in treatments done in China and South Korea, with clinical trial ongoing as of March 2020. Treatment with chloroquine tablets was reported to show favorable outcomes such as faster time to recover and shorter hospital stay in people with COVID-19 infections. Laboratory research from the US CDC shows chloroquine also has potential to treat prophylactically. Chloroquine is being investigated to treat COVID-19 in the form of chloroquine phosphate or hydroxychloroquine sulfate which are sometimes referred to as chloroquine and hydroxychloroquine respectively. As of March 26, 2020 the NIH Clinical Trials database showed 18 clinical trials listing hydroxychloroquine as an intervention.

Timeline

March 18, 2020

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

February 4, 2020

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

Meredith Hanel
Meredith Hanel edited on 26 March, 2020 1:06 pm
Edits made to:
Article (+39/-39 characters)
Article

Chloroquine has been reported to be an effective antiviral therapeutic against COVID-19 in treatments done in China and South Korea, with clinical trial ongoing as of March 2020. Treatment with chloroquine tablets was reported to show favorable outcomes such as faster time to recover and shorter hospital stay in people with COVID-19 infections. Laboratory research from the US CDC shows chloroquine also has potential to treat prophylactically. Chloroquine is being investigated to treat COVID-19 in the form of chloroquine phosphatechloroquine phosphate or hydroxychloroquinehydroxychloroquine sulfate which are sometimes referred to as chloroquine and hydroxychloroquine respectively.

Edits on 18 March, 2020
Meredith Hanel
Meredith Hanel edited on 18 March, 2020 11:56 pm
Edits made to:
Article
Article

The antiviral activity of chloroquine is thought to depend on the extent that the virus utilizes endosomes for entry. SARS-CoV-2 and other coronaviruses are enveloped viruses that use endocytosis prior to fusion with the host membrane. Post infection, chloroquine raises the pH and inhibits on-going fusion events between the virus and endosomes. Chloroquine is also thought to inhibit the replicative path of the virus. The drug enters cells and crosses endosomal membranes. Inside the endosome, nitorogens in chloroquine (and quinines) absorb hydrogen and prevent acidification, holding the endosome at a higher pH than is functional for the enzymes needed for hydrolysis reactions needed for coronavirus replication.

Meredith Hanel
Meredith Hanel edited on 18 March, 2020 11:47 pm
Edits made to:
Article (+203 characters)
Article

Chloroquine has been reported to be an effective antiviral therapeutic against COVID-19 in treatments done in China and South Korea, with clinical trial ongoing as of March 2020. Treatment with chloroquine tablets was reported to show favorable outcomes such as faster time to recover and shorter hospital stay in people with COVID-19 infections. Laboratory research from the US CDC shows chloroquine also has potential to treat prophylactically. Chloroquine is being investigated to treat COVID-19 in the form of chloroquine phosphate or hydroxychloroquine sulfate which are sometimes referred to as chloroquine and hydroxychloroquine respectively.

Meredith Hanel
Meredith Hanel edited on 18 March, 2020 11:25 pm
Edits made to:
Article (+8/-8 characters)
Article

Chloroquine has been reported to be an effective antiviral therapeutic against COVID-19COVID-19 in treatments done in China and South Korea, with clinical trial ongoing as of March 2020. Treatment with chloroquine tablets was reported to show favorable outcomes such as faster time to recover and shorter hospital stay in people with COVID-19 infections. Laboratory research from the US CDC shows chloroquine also has potential to treat prophylactically.

Meredith Hanel
Meredith Hanel edited on 18 March, 2020 11:25 pm
Edits made to:
Infobox (+1 properties)
Description (+89/-17 characters)
Article (+1203 characters)
Further reading (+4 rows) (+12 cells) (+514 characters)
Categories (+1 topics)
Topic thumbnail

Chloroquine

Chemical compound

Chemical compound and drug used to treat malaria, autoimmune disease and other conditions

Article

Chloroquine is quinoline derivative and a drug in widespread use since 1945 for treatment of malaria, autoimmune and other conditions. Chloroquine as an antimalarial agent given by tablet, syrup or injection as chloroquine phosphate or chloroquine sulfate. Chloroquine has been shown to inhibit parasitic enzyme heme polymerase that converts toxic heme into non-toxic hemazoin, resulting in accumulation of toxic heme inside the parasite. Chloroquine is also thought to interfere with biosynthesis of nucleic acids. The agent shows chemosensitizing and radiosensitizing activities in cancer which may be due to inhibition of autophagy. For malaria chloroquine is used for prevention and as therapy. Chloroquine treats extraintestinal amebiasis and acts as an anti-inflammatory agent in treating rheumatoid arthritis and lupus erythematosus. Chloroquine is not found in individuals unless they have taken the drug. The mechanism of action of chloroquine is not well understood. The drug does not have significant detrimental side effects and can be taken by children and pregnant and nursing mothers.

...

Chloroquine has been reported to be an effective antiviral therapeutic against COVID-19 in treatments done in China and South Korea, with clinical trial ongoing as of March 2020. Treatment with chloroquine tablets was reported to show favorable outcomes such as faster time to recover and shorter hospital stay in people with COVID-19 infections. Laboratory research from the US CDC shows chloroquine also has potential to treat prophylactically.

The antiviral activity of chloroquine is thought to depend on the extent that the virus utilizes endosomes for entry. SARS-CoV-2 and other coronaviruses are enveloped viruses that use endocytosis prior to fusion with the host membrane. Post infection, chloroquine raises the pH and inhibits on-going fusion events between the virus and endosomes. Chloroquine is also thought to inhibit the replicative path of the virus. The drug enters cells and crosses endosomal membranes. Inside the endosome, nitorogens in chloroquine (and quinines) absorb hydrogen and prevent acidification, holding the endosome at a higher pH than is functional for the enzymes needed for hydrolysis reactions needed for coronavirus replication.

As a preventative treatment prior to infection, chloroquine is thought to impair terminal glycosylation of the ACE2 receptor it uses to enter cells. This may result in reduced binding between ACE2 and the spike protein on SARS-CoV-2, inhibiting initiation of infection.

Further reading

Title
Author
Link
Type
Date

Notice on Adjusting the Usage and Dosage of Chloroquine Phosphate for the Treatment of Novel Coronavirus Pneumonia

Web

March 1, 2020

Novel Coronavirus Pneumonia Diagnosis and Treatment Plan (Provisional 7th Edition)

Web

March 4, 2020

Physicians work out treatment guidelines for coronavirus - Korea Biomedical Review

Web

February 13, 2020

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Categories
Meredith Hanel
Meredith Hanel edited on 18 March, 2020 9:42 pm
Edits made to:
Article (+1332 characters)
Article

Chloroquine is quinoline derivative and a drug in widespread use since 1945 for treatment of malaria, autoimmune and other conditions. Chloroquine as an antimalarial agent given by tablet, syrup or injection as chloroquine phosphate or chloroquine sulfate. Chloroquine has been shown to inhibit parasitic enzyme heme polymerase that converts toxic heme into non-toxic hemazoin, resulting in accumulation of toxic heme inside the parasite. Chloroquine is also thought to interfere with biosynthesis of nucleic acids. The agent shows chemosensitizing and radiosensitizing activities in cancer which may be due to inhibition of autophagy. For malaria chloroquine is used for prevention and as therapy. Chloroquine treats extraintestinal amebiasis and acts as an anti-inflammatory agent in treating rheumatoid arthritis and lupus erythematosus. Chloroquine is not found in individuals unless they have taken the drug. The mechanism of action of chloroquine is not well understood.

...

Chloroquine has been reported to be an effective antiviral therapeutic against COVID-19. Treatment with chloroquine tablets was reported to show favorable outcomes such as faster time to recover and shorter hospital stay in people with COVID-19 infections. Laboratory research from the US CDC shows chloroquine also has potential to treat prophylactically.

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