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Cara Therapeutics

Cara Therapeutics

A company developing treatments for pain, inflammation and pruritus

Cara Therapeutics is a publicly held biotechnology company based in Stamford, Connecticut that was founded in 2004 by Derek Chalmers, Frederique Menzaghi, and Michael E. Lewis. It is focused on developing therapeutics to treat pain, inflammation, and pruritus. This is done by selectively targeting peripheral kappa opiod receptors (KORs). 



Cara is developing a proprietary class of product candidates that target the body's peripheral nervous system and have demonstrated initial efficacy in patients with moderate-to-severe pain and pruritus (itch) without inducing many of the side effects typically associated with other pain and itch therapeutics.

Products

CR845

Cara's lead product candidate, CR845, is a potent peripheral kappa opiod receptor agonist with high selectivity over other opiod receptors in the body. It exhibits potent analgesic, anti-inflammatory, and anti-pruritic (anti-itch) properties in both human and animals. In addition, CR845 is intrinsically poor at penetrating the blood-brain barrier and therefore, has shown little side effects such as nausea/vomitting, sedation, respiratory depression, abuse, addiction, or euphoria. 

Korsuva

The product, Korsuva, has been formulated both as an IV and oral formulation and is being studied for acute pain, chronic pain, and uremic pruritus (itch). An injectible version of Korsuva is ready for commercialization, while the oral version for Puritus CKD and Pruritus CLD are in Phase 3 and Phase 2 of clinical studies respectively. An IV Difelikefalin version of CR845 is ready for commercialization for use in post-op settings and another oral Difelikefalin version has completed Phase 3 clinical studies for chronic pain and is progressing to commercialization.

CR701

Cara also has a product in preclinical development. CR701 selectively modulates CB receptors without targeting CNS cannabinoid receptors. It is intended to be developed as a therapeutic approach for neuropathic pain. The product has been evaluated in rodent models of neuropathic pain that produces both hyperalgesia (sensitization of nerve endings to painful stimuli) and allodynia (painful perception of innocuous stimuli) comparable to human conditions.



Timeline

Funding rounds

3 Results
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People

Name
Role
LinkedIn

Angelo Calvello

Investor



Daniel M. Houde

Employee



Daniel Sarraf

Investor



Derek Chalmers

CEO, President, & Director



Eric Vandal

VP of Commercial Operations



Frederique Menzaghi

Senior VP of Research and Development



Jo Goncalves

Chief Medical Officer



Joe Stauffer

Employee



Jonathan Morgan

Investor



Mani Mohindru

CFO & Chief Strategy Officer



Michael E. Lewis

Chief Scientific Advisor



Nathan Low

Investor



Randy Anthony

Investor



Scott Terrillion

General Counsel



William O. Pate II

Investor



Further reading

Title
Author
Link
Type
Date

Cara Therapeutics Appoints Christopher A. Posner to Board of Directors

CNBC

Web



Jefferies Projects $573M Peak Sales For Cara Therapeutics' Lead Candidate (NASDAQ:CARA)

Shanthi Rexaline

Web



Documentaries, videos and podcasts

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Companies

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References