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Cap-dependent endonuclease (CEN)

An essential enzyme for the initiation of mRNA synthesis in influenza viruses.

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Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently suppresses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse models

Keita Fukao, Yoshinori Ando, Takeshi Noshi, Mitsutaka Kitano, Takahiro Noda, Makoto Kawai, Ryu Yoshida, Akihiko Sato, Takao Shishido, Akira Naito

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May 20, 2019

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