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CRISPR

CRISPR

Clustered regularly interspaced short palindromic repeats (CRISPR) is a prokaryotic adaptive immune response that provides immunity against foreign nucleic acids, such as viral DNA and bacterial plasmids, through the use of crRNAs (CRISPR RNAs) and associated Cas genes.

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Edits on 22 Apr, 2023
Katrina-Kay Pettitt"prospector:2667:2703585"
Katrina-Kay Pettitt edited on 22 Apr, 2023
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Edits on 5 Apr, 2023
Jen English
Jen English edited on 5 Apr, 2023
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Related Organization
Editas Medicine
Editas Medicine
Beam Therapeutics
Beam Therapeutics
CRISPR Therapeutics
CRISPR Therapeutics
Verve Therapeutics
Verve Therapeutics
Edits on 27 Oct, 2022
Chu Li
Chu Li edited on 27 Oct, 2022
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Infobox (+13/-2 properties)
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Technology
Technology
Is a
Organization
Organization
Organization
Organization
Created/Discovered by
Jennifer Doudna
Jennifer Doudna
Emmanuelle Charpentier
Emmanuelle Charpentier
Feng Zhang
Feng Zhang
Related Organization
Editas Medicine
Editas Medicine
Beam Therapeutics
Beam Therapeutics
CRISPR Therapeutics
CRISPR Therapeutics
Verve Therapeutics
Verve Therapeutics
Related Technology
CRISPR/Cas Tools
CRISPR/Cas Tools
Perturb-seq
Perturb-seq
Epigenetic CRISPR/Cas9
Epigenetic CRISPR/Cas9
CRISPR-Cas9
CRISPR-Cas9
Date Invented
2020
Edits on 1 May, 2022
Temo Iosava
Temo Iosava edited on 1 May, 2022
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Edits on 20 Apr, 2022
Nika Nika
Nika Nika edited on 20 Apr, 2022
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Title
Date
Link

Genome Editing with CRISPR-Cas9

November 5, 2014

https://www.youtube.com/watch?v=2pp17E4E-O8

Edits on 14 Mar, 2022
Anton Iemtsev
Anton Iemtsev edited on 14 Mar, 2022
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Categories
  • Topic thumbnailMolecular biology
Anton Iemtsev
Anton Iemtsev edited on 14 Mar, 2022
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Categories
  • Topic thumbnailBiochemistry
Edits on 27 Feb, 2020
Golden AI"Attach Wikidata entity ID"
Golden AI edited on 27 Feb, 2020
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Wikidata entity ID
Q412563
Edits on 24 Jun, 2019
Carla Faraguna
Carla Faraguna edited on 24 Jun, 2019
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CRISPR babies: when will the world be ready?

https://www.nature.com/articles/d41586-019-01906-z

Web

June 19, 2019

Edits on 28 Feb, 2019
Alex Dean
Alex Dean edited on 28 Feb, 2019
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Name
Role
Related Golden topics

Emmanuelle Charpentier

Jennifer DoudnaJennifer Doudna

Researcher

Alex Dean
Alex Dean edited on 28 Feb, 2019
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Company
CEO
Location
Products/Services

Crispr Therapeutics

Samarth Kulkarni

Zug, Switzerland

Editas Medicine

Katrine Bosley

Cambridge, Massachusetts, USA

Intellia Therapeutics

John M. Leonard

Cambridge, Massachusetts, USA

Edits on 14 Nov, 2018
Jude Gomila
Jude Gomila approved a suggestion from Golden's AI on 14 Nov, 2018
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Related Topics (+1 topics)
Related Topics
  • Topic thumbnailPerturb-seq
Edits on 30 Oct, 2018
Carla Faraguna
Carla Faraguna edited on 30 Oct, 2018
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Related Topics
  • Topic thumbnailCRISPR-Cas13d
Carla Faraguna
Carla Faraguna edited on 30 Oct, 2018
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Related Topics
  • Topic thumbnailCRISPR-Cas12d
  • Topic thumbnailCRISPR-Cas12e
  • Topic thumbnailCRISPR-Cas9
  • Topic thumbnailAnti-CRISPR Proteins (Acr Proteins)
  • Topic thumbnailCRISPR-Cas13a
  • Topic thumbnailCRISPR-Cas13b
Edits on 20 Sep, 2018
Carla Faraguna
Carla Faraguna edited on 20 Sep, 2018
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Will You Eat CRISPR Produce? - NEO.LIFE - Medium

Shelby Pope

https://medium.com/neodotlife/crispr-food-aa074305cf5c

Web

Edits on 16 Aug, 2018
Carla Faraguna
Carla Faraguna edited on 16 Aug, 2018
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10 High Potential CRISPR Startups to Watch Out In 2018

https://explorebiotech.com/10-crispr-startups-to-watch-2018/

Article

Edits on 7 Aug, 2018
Golden AI"Linkify text links in standard tables"
Golden AI edited on 7 Aug, 2018
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Emily Mullin

U.S. Doctors Plan to Treat Cancer Patients Using CRISPR

https://www.technologyreview.com/s/609999/us-doctors-plan-to-treat-cancer-patients-using-crispr/?utm_source=twitter.com&utm_medium=social&utm_content=2018-01-17&utm_campaign=Technology+Reviewhttps://www.technologyreview.com/s/609999/us-doctors-plan-to-treat-cancer-patients-using-crispr/?utm_source=twitter.com&utm_medium=social&utm_content=2018-01-17&utm_campaign=Technology+Review

The Verge

Gene-editing tool CRISPR can now manipulate more types of genetic material

https://www.theverge.com/2017/10/25/16543004/crispr-cas13-rna-gene-editing-disease-treatmenthttps://www.theverge.com/2017/10/25/16543004/crispr-cas13-rna-gene-editing-disease-treatment

Article

Edits on 29 Jul, 2018
Logan Frederick"Added additional reading material on the subject, including prominent books."
Logan Frederick edited on 29 Jul, 2018
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Topic thumbnail

CRISPR

Clustered regularly interspaced short palindromic repeats (CRISPR) is a prokaryotic adaptive immune response that provides immunity against foreign nucleic acids, such as viral DNA and bacterial plasmids, through the use of crRNAs (CRISPR RNAs) and associated Cas genes.

Table

Name
Role
Related Golden topics

Jennifer Doudna

Researcher

Table

Author
Title
Link
Type

James Kozubek

Modern Prometheus: Editing the Human Genome with Crispr-Cas9

https://www.amazon.com/Modern-Prometheus-Editing-Genome-Crispr-Cas9/dp/1107172160/ref=sr_1_11?ie=UTF8&qid=1532898756&sr=8-11&keywords=crispr

Book

Siddhartha Mukherjee

The Gene: An Intimate History eBook: Siddhartha Mukherjee: Kindle Store

https://www.amazon.com/Gene-Intimate-History-Siddhartha-Mukherjee-ebook/dp/B017I25DCC/ref=sr_1_4?ie=UTF8&qid=1532898756&sr=8-4&keywords=crispr&dpID=417RAmvqvFL&preST=_SY445_QL70_&dpSrc=srch

Book

The Verge

Gene-editing tool CRISPR can now manipulate more types of genetic material

https://www.theverge.com/2017/10/25/16543004/crispr-cas13-rna-gene-editing-disease-treatment

Article

Edits on 25 May, 2018
Tianchang He
Tianchang He edited on 25 May, 2018
Edits made to:
Article (+3/-3 characters)
Article

Clustered regularly interspaced short palindromic repeats (CRISPR) is a prokaryotic adaptive immune response that provides immunity against foreign nucleic acids, particularly viral DNA or RNARNA, through the use of crRNAs (CRISPR RNAs) and associated Cas genes.

Edits on 15 May, 2018
Tianchang He
Tianchang He edited on 15 May, 2018
Edits made to:
Article (+4/-4 characters)
Article

The CRISPR response evolved to defend bacteria and archaea against infection with bacteriophages, and CRISPR genes are present in the majority of bacterial and archaeal genomes. CRISPR systems share several common features: first, a mechanism for recognition and processing of foreign nucleic acids into short 'spacer' sequences; second, a mechanism for incorporation of these spacers into clusters (CRISPRs) on the bacterial genome, which are regularly interspersed by a short, repeated palindromic DNA sequence; third, a mechanism for transcribing and processing this CRISPR sequence into RNA molecules (known as CRISPR RNAs, or crRNAs) comprising the spacer sequence and a hairpin formed by the palindromic repeat; and finally, recognition and cleavage of DNA or RNA matching the spacer sequence by a protein-RNA complex consisting of both the crRNA and a nuclease. To avoid self-cleavage of the CRISPR locus in the microbe's genome, spacer sequences must occur next to a short DNA sequence, called the Protospacer-Adjacent Motif (PAM), which is not present in the CRISPR locus of the genome. This PAM sequence must be present in order for a spacer to be incorporated into the CRISPR locus, and must be present next to DNA/RNA matching the spacer in order for the crRNA/nuclease complex to recognize and cleave it. The genes and proteins involved with spacer acquisition, crRNA processing, and crRNA-guided cleavage are named CRISPR-Associated (Cas). In type II CRISPR systems, a single gene called Cas9Cas9 produces a DNA endonuclease which binds to the crRNA (which, when fused with a trans-activating crRNA, is called a short guide RNA or sgRNA), and can bind and introduce DNA double strand breaks at sequences matching the crRNA's spacer region. The Cas9/sgRNA complex can be programmed to cleave any PAM-adjacent DNA sequence, simply by changing the the spacer (also known as the guide) sequence. Cas nucleases from type V CRISPR systems (such as Cpf1/Cas12A) have also been adapted to programmably cleave DNA, while nucleases from type VI CRISPR systems (such as C2c2/Cas13A) have been adapted to programmably cleave RNA.

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