CRISPR-Cas9 is a genome editing system. CRISPR systems provides immunity to bacteria and archaea from viruses and has been adapted for use as a genome editing tool capable of knocking out genes and rewriting genetic sequences in animal, plant and fungi. CRISPR-Cas9 is being adapted to other applications outside genome editing.
Editas MedicineEditas Medicine is developing a CRISPR-Cas9 therapy for Leber Hereditary Amaurosis . Autosomal recessive and autosomal dominant Retinitis Pigmentosa, choroidal neovascularization and Age-Related Macular Degeneration are forms of blindness that are being tested with CRISPR-Cas9 preclinically in animal models .