A nucleic acid editing technology that targets RNA, analogous to the CRISPR-Cas9 system

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Carla Faraguna
Carla Faraguna edited on 4 Apr 2018 9:42 pm
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Carla Faraguna
Carla Faraguna edited on 4 Apr 2018 9:32 pm
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CRISPR-Cas13 is also known as CRISPR-Cas Type VI and used to be known as C2c2. It is analogous to the CRISPR-Cas9 system. However, unlike Cas-9 which targets DNA, Cas-13 targets and cleaves single stranded RNA. One member of the Cas13 enzyme family, Cas-13a, can be used to knockdown mammalian cell RNA and reduce the expression of an organisms genes.

Cas-13 was first discovered in L. shahii, a species of the Leptotrichia bacteria while researchers were looking for previously unidentified CRISPR systems.

Academic papers


Abudayyeh et al.

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector


Paper published on in vivo RNA targeting 

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