COVID-19

COVID-19

COVID-19 is the abbreviated name for coronavirus disease 2019, a respiratory disease caused by a novel coronavirus strain called SARS-CoV-2.

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Edits on 20 Jul, 2020
Holden Page
Holden Page edited on 20 Jul, 2020
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ImmunoPrecise Antibodies
Edits on 10 Apr, 2020
Golden AI
Golden AI edited on 10 Apr, 2020
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ImmunoPrecise Antibodies
Edits on 2 Apr, 2020
Meredith Hanel
Meredith Hanel edited on 2 Apr, 2020
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A study from Shenzhen China suggests that obesity increases the risk of developing pneumonia in COVID-19 patients. The association was more clear for men than women due to small number of women in the obesity group.

Edits on 18 Mar, 2020
Carla Faraguna
Carla Faraguna edited on 18 Mar, 2020
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Further reading

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ClinicalTrials.gov

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NCBI Virus

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SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) Sequences

Web

Edits on 18 Mar, 2020
Carla Faraguna
Carla Faraguna edited on 18 Mar, 2020
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Further reading

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Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

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Edits on 16 Mar, 2020
Neelam Jhaveri
Neelam Jhaveri approved a suggestion from Golden's AI on 16 Mar, 2020
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ACE2 mRNA expression in adipose is higher than in lung tissue, indicating adipose tissueadipose tissue may be another vulnerable site for SARS-CoV-2. As obese individuals have more adipose tissue, they may be more severely affected. Certain types of tumour tissue also have a higher expression of ACE2. There is no research to demonstrate that SARS-CoV-2 infects adipose tissue, but adipose tissue has been proposed as a reservoir for human adenovirus Ad-336, influenza A virus, HIV, cytomegalovirus Trypanosoma gondii and Mycobacterium tuberculosis. Obesity has been reported to increase vulnerability to infection and increases the duration of influenza transmission. This information has was brought together by a team at the PLA General Hospital, Beijing in their report suggesting that special attentioin should be given to COVID-19 patients that have obesity or one of the following five types of cancer: CESC, PAAD, READ, KIRP and KIRC.

Neelam Jhaveri
Neelam Jhaveri approved a suggestion from Golden's AI on 16 Mar, 2020
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ACE2 mRNA expression in adipose is higher than in lung tissue, indicating adipose tissue may be another vulnerable site for SARS-CoV-2. As obese individuals have more adipose tissue, they may be more severely affected. Certain types of tumour tissue also have a higher expression of ACE2. There is no research to demonstrate that SARS-CoV-2 infects adipose tissue, but adipose tissue has been proposed as a reservoir for human adenovirus Ad-336, influenza A virus, HIV, cytomegalovirus Trypanosoma gondii and Mycobacterium tuberculosis. Obesity has been reported to increase vulnerability to infection and increases the duration of influenza transmission. This information has was brought together by a team at the PLA General Hospital, BeijingBeijing in their report suggesting that special attentioin should be given to COVID-19 patients that have obesity or one of the following five types of cancer: CESC, PAAD, READ, KIRP and KIRC.

Edits on 15 Mar, 2020
Aime Anne Nisay
Aime Anne Nisay approved a suggestion from Golden's AI on 15 Mar, 2020
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ACE2 mRNA expression in adipose is higher than in lung tissue, indicating adipose tissue may be another vulnerable site for SARS-CoV-2. As obese individuals have more adipose tissue, they may be more severely affected. Certain types of tumour tissue also have a higher expression of ACE2. There is no research to demonstrate that SARS-CoV-2 infects adipose tissue, but adipose tissue has been proposed as a reservoir for human adenovirus Ad-336, influenza A virus, HIV, cytomegalovirus Trypanosoma gondii and Mycobacterium tuberculosisMycobacterium tuberculosis. Obesity has been reported to increase vulnerability to infection and increases the duration of influenza transmission. This information has was brought together by a team at the PLA General Hospital, Beijing in their report suggesting that special attentioin should be given to COVID-19 patients that have obesity or one of the following five types of cancer: CESC, PAAD, READ, KIRP and KIRC.

Meredith Hanel
Meredith Hanel edited on 14 Mar, 2020
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Article

ACE2 mRNA expression in adipose is higher than in lung tissue, indicating adipose tissue may be another vulnerable site for SARS-CoV-2. As obese individuals have more adipose tissue, they may be more severely affected. Certain types of tumour tissue also have a higher expression of ACE2. There is no research to demonstrate that SARS-CoV-2 infects adipose tissue, but adipose tissue has been proposed as a reservoir for human adenovirus Ad-336, influenza A virus, HIV, cytomegalovirus Trypanosoma gondii and Mycobacterium tuberculosis. Obesity has been reported to increase vulnerability to infection and increases the duration of influenza transmission. This information has was brought together by a team at the PLA General Hospital, Beijing toin suggesttheir report suggesting that special attentioin should be given to COVID-19 patients that have obesity or one of the following five types of cancer: CESC, PAAD, READ, KIRP and KIRC.

Meredith Hanel
Meredith Hanel edited on 14 Mar, 2020
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ACE2, obesity and cancer

ACE2 mRNA expression in adipose is higher than in lung tissue, indicating adipose tissue may be another vulnerable site for SARS-CoV-2. As obese individuals have more adipose tissue, they may be more severely affected. Certain types of tumour tissue also have a higher expression of ACE2. There is no research to demonstrate that SARS-CoV-2 infects adipose tissue, but adipose tissue has been proposed as a reservoir for human adenovirus Ad-336, influenza A virus, HIV, cytomegalovirus Trypanosoma gondii and Mycobacterium tuberculosis. Obesity has been reported to increase vulnerability to infection and increases the duration of influenza transmission. This information has was brought together by a team at the PLA General Hospital, Beijing to suggest that special attentioin should be given to COVID-19 patients that have obesity or one of the following five types of cancer: CESC, PAAD, READ, KIRP and KIRC.

Edits on 11 Mar, 2020
Charlie Hilton
Charlie Hilton edited on 11 Mar, 2020
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Charlie Hilton
Charlie Hilton edited on 11 Mar, 2020
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COVID-19

COVID-19 is the abbreviated name for coronavirus disease 2019, a respiratory disease caused by a novel coronavirus strain called SARS-CoV-2.

Meredith Hanel
Meredith Hanel edited on 11 Mar, 2020
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COVID-19 is the abbreviated name for coronavirus disease 2019, a respiratory disease caused by a novel coronavirus strain called SARS-CoV-2. COVID-19 was first detected in Wuhan City, China and the outbreak was declared a public health emergency of international concern on January 30, 2020 by the World Health Organization (WHO). On March 11 the WHO stated that the COVID-19 outbreak is characterized as a pandemic, meaning worldwide spread.

Edits on 10 Mar, 2020
Aime Anne Nisay
Aime Anne Nisay approved a suggestion from Golden's AI on 10 Mar, 2020
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SARS-CoV-2 uses the serine protease TMPRSS2 for S protein priming, or cleavage of the S protein, which is part of the process for fusion between the virus and the host cell. TPRSS2 is considered a host cell factor critical for spread of clinically relevant viruses such as influenza A viruses and coronaviruses. As TMPRSS2 is not needed for development or homeostasis, it provides a potential drug target. The serine protease inhibitor camostatcamostat mesylate blocks TMPRSS2 and is a drug approved in Japan for human use to treat chronic pancreatitis and post operative reflux esophagitis. Camostat mesylate has been shown to be effective in mice infected with SARS-CoV. The drug has been shown experimentally to block infection of cells in culture with SARS-CoV-2-like particles and with authentic SARS-CoV-2.

Charlie Hilton
Charlie Hilton approved a suggestion from Golden's AI on 10 Mar, 2020
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COVID-19 is the abbreviated name for coronavirus disease 2019, a respiratory disease caused by a novel coronavirus strain called SARS-CoV-2. COVID-19 was first detected in WuhanWuhan City, China and the outbreak was declared a public health emergency of international concern on January 30, 2020 by the World Health Organization (WHO).

Charlie Hilton
Charlie Hilton approved a suggestion from Golden's AI on 10 Mar, 2020
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A phylogenetic analysis of SARS-CoV-2 traced the likely origins of the virus to bats. Ten genome sequences of SARS-CoV-2 (2019-nCoV) from nine patients were found to have 99.98% sequence identity. SARS-CoV-2 (2019-nCoV) showed 88% identity to two bat-derived SARS-like coronaviruses, 79% identity to SARS-CoV and 50% identity to MERS-CoV. The analysis suggests that bats may be the original host and an animal sold at the seafood market may have served as an intermediate host before the virus emerged in humans. SARS-CoV-2 possesses a similar genetic organization to bat-SL-CoVZC45, bat-SL-CoVZXC21, and SARS-CoV, and the majority of it's protein coding regions are similar to bat-SL-CoVZC45, and bat-SL-CoVZXC21 with only minor insertions or deletions. One of the most notable differences was that SARS-CoV-2 sequences encoded a longer spike proteinspike protein than other bat SARS-like coronaviruses, SARS-CoV and MERS-CoV.

Henry Ogolla
Henry Ogolla approved a suggestion from Golden's AI on 9 Mar, 2020
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COVID-19 is the abbreviated name for coronavirus disease 2019, a respiratory disease caused by a novel coronavirus strain called SARS-CoV-2. COVID-19 was first detected in Wuhan City, ChinaChina and the outbreak was declared a public health emergency of international concern on January 30, 2020 by the World Health Organization (WHO).

Henry Ogolla
Henry Ogolla approved a suggestion from Golden's AI on 9 Mar, 2020
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Article (+5/-5 characters)
Article

SARS-CoV-2 uses the serine protease TMPRSS2 for S protein priming, or cleavage of the S protein, which is part of the process for fusion between the virus and the host cell. TPRSS2 is considered a host cell factor critical for spread of clinically relevant viruses such as influenza A viruses and coronaviruses. As TMPRSS2 is not needed for development or homeostasis, it provides a potential drug target. The serine protease inhibitor camostat mesylate blocks TMPRSS2 and is a drug approved in JapanJapan for human use to treat chronic pancreatitis and post operative reflux esophagitis. Camostat mesylate has been shown to be effective in mice infected with SARS-CoV. The drug has been shown experimentally to block infection of cells in culture with SARS-CoV-2-like particles and with authentic SARS-CoV-2.

Meredith Hanel
Meredith Hanel edited on 9 Mar, 2020
Edits made to:
Article (+1/-2 characters)
Article

SARS-CoV-2 uses the serine protease TMPRSS2 for S protein priming, or cleavage of the S protein, which is part of the process for fusion between the virus and the host cell. TPRSS2 is considered a host cell factor critical for spread of clinically relevant viruses such as influenza A viruses and coronaviruses. As TMPRSS2 is not needed for development or homeostasis, it provides a potential drug target. The serine protease inhibitor camostat mesylate blocks TMPRSS2 and is ana drug approved in Japan for human use to treat chronic pancreatitis and post operative reflux esophagitis. Camostat mesylate has been shown to be effective in mice infected with SARS-CoV. The drug has been shown experimentally to block infection of cells in culture with SARS-CoV-2-like particles and with authentic SARS-CoV-2.

Meredith Hanel
Meredith Hanel edited on 9 Mar, 2020
Edits made to:
Article (+812 characters)
Article

TMPRSS2

SARS-CoV-2 uses the serine protease TMPRSS2 for S protein priming, or cleavage of the S protein, which is part of the process for fusion between the virus and the host cell. TPRSS2 is considered a host cell factor critical for spread of clinically relevant viruses such as influenza A viruses and coronaviruses. As TMPRSS2 is not needed for development or homeostasis, it provides a potential drug target. The serine protease inhibitor camostat mesylate blocks TMPRSS2 and is an drug approved in Japan for human use to treat chronic pancreatitis and post operative reflux esophagitis. Camostat mesylate has been shown to be effective in mice infected with SARS-CoV. The drug has been shown experimentally to block infection of cells in culture with SARS-CoV-2-like particles and with authentic SARS-CoV-2.

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