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Bioprinting

Bioprinting

A method for creating replacement skin, bone, muscle and organs.

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Edits on 22 Oct 2018
Carla Faraguna
Carla Faraguna edited on 22 Oct 2018 11:46 pm
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Bioprinting

Imagine beingA ablemethod tofor printcreating replacement skin, bone, muscle and even organs.

Article

Bioprinters work in almost the exact same way aslike 3D printers, with one key difference. Instead of delivering materials such as plastic, ceramic, metal or food,but theyinstead deposit layers of biomaterial, that may includeincluding living cells, to build complex structures like blood vessels or skin tissue.



Researchers hope that, in the future, bioprinted bones could be created with enough reliability to underpin intricate spinal reconstruction, and that the bone material could be further improved to enhance its compatibility with cartilage cells.

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The required cells ( e.g. kidney cells, skin cells, etc) are taken from a patient and then cultivated. Adult stem cells, which can develop to form the cells required in different tissues, can also be used. The resulting cultured cells are usedreferred to as the bioink. Cells contained in a bioink spheroid are capable of rearranging themselves after printing. For example, experimental blood vessels have been bioprinted using bioink spheroids comprised of an aggregate mix of endothelial, smooth muscle and fibroblast cells. Once placed in position by the bioprint head, and with no technological intervention, the endothelial cells migrate to the inside of the bioprinted blood vessel, the smooth muscle cells move to the middle, and the fibroblasts migrate to the outside.



Cells contained in a bioink spheroid are capable of rearranging themselves after printing. For example, experimental blood vessels have been bioprinted using bioink spheroids comprised of an aggregate mix of endothelial, smooth muscle and fibroblast cells. Once placed in position by the bioprint head, and with no technological intervention, the endothelial cells migrate to the inside of the bioprinted blood vessel, the smooth muscle cells move to the middle, and the fibroblasts migrate to the outside.

Edits on 19 Oct 2018
Jude Gomila
Jude Gomila approved a suggestion from Golden's AI on 19 Oct 2018 10:09 pm
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Article

Bioprinters work in almost the exact same way as 3D printers, with one key difference. Instead of delivering materials such as plastic, ceramic, metal or food, they deposit layers of biomaterial, that may include living cells, to build complex structures like blood vesselsblood vessels or skin tissue.

Edits on 18 Oct 2018
Carla Faraguna
Carla Faraguna edited on 18 Oct 2018 11:22 pm
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OrganovoOrganovo is a company that was set up by a research group lead by Professor Gabor Forgacs from the University of Missouri, and in March 2008 bioprinted functional blood vessels and cardiac tissue using cells obtained from a chicken. Their work relied on a prototype bioprinter with three print heads. The first two of these output cardiac and endothelial cells, while the third dispensed a collagen scaffold -- now termed 'bio-paper' -- to support the cells during printing.

Carla Faraguna
Carla Faraguna edited on 18 Oct 2018 11:22 pm
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Topic thumbnail

Bioprinting

Imagine being able to print replacement skin, bone, muscle and even organs.

Article

Bioprinters work in almost the exact same way as 3D printers, with one key difference. Instead of delivering materials such as plastic, ceramic, metal or food, they deposit layers of biomaterial, that may include living cells, to build complex structures like blood vessels or skin tissue.





Researchers hope that, in the future, bioprinted bones could be created with enough reliability to underpin intricate spinal reconstruction, and that the bone material could be further improved to enhance its compatibility with cartilage cells.



Organovo is a company that was set up by a research group lead by Professor Gabor Forgacs from the University of Missouri, and in March 2008 bioprinted functional blood vessels and cardiac tissue using cells obtained from a chicken. Their work relied on a prototype bioprinter with three print heads. The first two of these output cardiac and endothelial cells, while the third dispensed a collagen scaffold -- now termed 'bio-paper' -- to support the cells during printing.



Bioink

The required cells ( e.g. kidney cells, skin cells, etc) are taken from a patient and then cultivated. Adult stem cells, which can develop to form the cells required in different tissues, can also be used. The resulting cultured cells are used as the bioink.



Cells contained in a bioink spheroid are capable of rearranging themselves after printing. For example, experimental blood vessels have been bioprinted using bioink spheroids comprised of an aggregate mix of endothelial, smooth muscle and fibroblast cells. Once placed in position by the bioprint head, and with no technological intervention, the endothelial cells migrate to the inside of the bioprinted blood vessel, the smooth muscle cells move to the middle, and the fibroblasts migrate to the outside.

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Use cases

Progress in drug testing and regenerative medicine could benefit from laboratory-engineered human tissues built of a variety of cell types with precise 3D architecture. Production of greater than millimeter sized human tissues has been limited by a lack of methods for building tissues with embedded life-sustaining vascular networks.

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Edits on 11 Oct 2018
Carla Faraguna
Carla Faraguna edited on 11 Oct 2018 4:02 pm
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Companies (+12/-12 characters)

Companies

Company
CEO
Location
Products/Services

SunP BiotechSunP Biotech

Wei Sun, Phd

Beijing, CHINA

Bioprinters

Sean Greenwood
Sean Greenwood edited on 11 Oct 2018 7:57 am
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Companies (+4 cells) (+49 characters)

Companies

Company
CEO
Location
Products/Services

Aether

Ryan Franks

San Francisco, CA USA

Bioprinters

Sean Greenwood
Sean Greenwood edited on 11 Oct 2018 7:54 am
Edits made to:
Companies (+4 cells) (+49 characters)

Companies

Company
CEO
Location
Products/Services

SunP Biotech

Wei Sun, Phd

Beijing, CHINA

Bioprinters

Sean Greenwood
Sean Greenwood edited on 11 Oct 2018 7:30 am
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Bio printing Bioprinting

A method for creating replacement skin, bone, muscle and organs.

Sean Greenwood"Initial topic creation"
Sean Greenwood created this topic on 11 Oct 2018 7:28 am
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 Bio printing

A method for creating replacement skin, bone, muscle and organs.

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