Azithromycin

Azithromycin

Chemical compound and macroslide antibiotic used to treat bacterial infections as well as chronic inflammatory disorders

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Edits on 15 June, 2020
Golden AI"Add external identifiers"
Golden AI edited on 15 June, 2020 9:54 pm
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Canonical SMILES
CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O
CAS Registry Number
83905-01-5
ChEMBL ID
CHEMBL529
DSSTox ID
DTXSID8030760
UNII
J2KLZ20U1M
Edits on 27 March, 2020
Neelam Jhaveri
Neelam Jhaveri approved a suggestion from Golden's AI on 27 March, 2020 6:15 am
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Hydroxychloroquine a chloroquine derivative, given alone and in combination with the the antibiotic azithromycin (aka Zithromas or Azithrocin) has shown early evidence of being effective in treating COVID-19 in preliminary results in a small study on 30 patients in FranceFrance. Azithromycin was given to some patients to prevent bacterial super-infection and the combination therapy appeared to be more effective than hydroxychloroquine alone. It is not clear if differences between patients that received hydroxychoroquine alone and the combination therapy may be due to differences in the patient's viral load between the two groups. In March 2020 the FDA cleared New York sites to use hydroxychloroquine and Zithromax (azithromycin) together as treatment for COVID-19 in clinical trials.

Neelam Jhaveri
Neelam Jhaveri approved a suggestion from Golden's AI on 27 March, 2020 5:16 am
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Hydroxychloroquine a chloroquine derivative, given alone and in combination with the the antibiotic azithromycin (aka Zithromas or Azithrocin) has shown early evidence of being effective in treating COVID-19 in preliminary results in a small study on 30 patients in France. Azithromycin was given to some patients to prevent bacterial super-infection and the combination therapy appeared to be more effective than hydroxychloroquine alone. It is not clear if differences between patients that received hydroxychoroquine alone and the combination therapy may be due to differences in the patient's viral load between the two groups. In March 2020 the FDA cleared New YorkNew York sites to use hydroxychloroquine and Zithromax (azithromycin) together as treatment for COVID-19 in clinical trials.

Edits on 26 March, 2020
Meredith Hanel
Meredith Hanel edited on 26 March, 2020 8:49 pm
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Azithromycin

Chemical compound

Chemical compound and macroslide antibiotic used to treat bacterial infections as well as chronic inflammatory disorders

Article

HydroxychloroquineHydroxychloroquine a chloroquine derivative, given alone and in combination with the the antibiotic azithromycin azithromycin (aka Zithromas or Azithrocin) havehas shown early evidence of being effective in treating COVID-19 in preliminary results in a small study on 30 patients in France. Azithromycin was given to some patients to prevent bacterial super-infection and the combination therapy appeared to be more effective than hydroxychloroquine alone. It is not clear if differences between patients that received hydroxychoroquine alone and the combination therapy may be due to differences in the patient's viral load between the two groups. In March 2020 the FDA cleared New York sites to use hydroxychloroquine and Zithromax (azithromycin) together as treatment for COVID-19 in clinical trials.

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Meredith Hanel
Meredith Hanel edited on 26 March, 2020 8:46 pm
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Azithromycin also known by the brand name Zithromax is a macrolide, broad-spectrum antibacterial that inhibits bacterial protein synthesis, quorum-sensing and reduces the formation of biofilm. Macroslides are a class of drugs that possess a macrocyclic lactone ring of 12 or more elements. Independent of their antimicrobial properties, azithromycin and other macroslides have immunomodulatory effects.

Azithromycin is a semi-synthetic derivative of erythromycin. Azithromycin accumulates in phagocytes at sites of inflammation and to a less and varying extent in other cells such as epithelial cells, fibroblasts, lymphocytes and hepatocytes.

Azithromycin is indicated for bacterial infections of respiratory, urogenital, dermal and other areas of the body. Pneumococcal macrolide resistance is linked to increased clinical use of macrolide antibiotics.

The drug has immunomodulatory effects in chronic inflammatory disorders such as diffuse panbronchiolitis, post-transplant bronchiolitis and rosacea. Azithromycin modulates host immune response with long-term therapeutic benefit in cystic fibrosis, non-cystic fibrosis bronchiectasis, exacerbations of chronic obstructive pulmonary disease (COPD) and non-eosinophilic asthma. Azithromycin has stimulatory effects on immune and epithelial cells through interactions with phospholipids and Erk1/2 which may promote host defense. The drug later modulates transcription factors AP-1, NFkB, inflammatory cytokine and mucin release which may reduce bystander tissue injury and resolve inflammation.

COVID-19

Hydroxychloroquine alone and in combination with the the antibiotic azithromycin (aka Zithromas or Azithrocin) have shown early evidence of being effective in treating COVID-19 in preliminary results in a small study on 30 patients in France. Azithromycin was given to some patients to prevent bacterial super-infection and the combination therapy appeared to be more effective than hydroxychloroquine alone. It is not clear if differences between patients that received hydroxychoroquine alone and the combination therapy may be due to differences in the patient's viral load between the two groups. In March 2020 the FDA cleared New York sites to use hydroxychloroquine and Zithromax (azithromycin) together as treatment for COVID-19 in clinical trials.

Edits on 27 February, 2020
Golden AI"Attach Wikidata entity ID"
Golden AI edited on 27 February, 2020 11:19 am
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Wikidata entity ID
Q165399
Edits on 1 January, 2017
Golden AI"Initial topic creation"
Golden AI created this topic on 1 January, 2017 12:00 am
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 Azithromycin

Chemical compound

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