DNA synthesis, the ability to "write" DNA, is a technology in life sciences research and engineering. Ansa Biotechnologies is developing a DNA synthesis technology that use enzymatic DNA synthesis to make DNA.
Soon after the discovery of "polymerase" enzymes that copy DNA, scientists have attempted of harness a polymerase to "write" desired sequences. One particular polymerase, Terminal Deoxynucleotidyl Transferase (TdT), has been considered the prime candidate for this purpose because, unlike all other polymerases that copy an existing sequence, TdT creates random DNA. In order to harness TdT for the synthesis of a desired sequence, its activity must be controlled so that it adds a single base to a DNA molecule and then stops, so the desired sequence can be synthesized step-by-step. Proposals to employ TdT for the stepwise synthesis of desired sequences date back to the early 1960s. However, controlling TdT's additions while maintaining its fast incorporation kinetics has proven to be difficult. Ansa are developing a new a technique to control additions of a polymerase that use TdT for de novo DNA synthesis.
Researchers pioneer DNA synthesis method that creates genes faster
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