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Ansa Biotechnologies

Ansa Biotechnologies

DNA synthesis company using enzymatic DNA synthesis.

DNA synthesis, the ability to write DNA, is a technology in life sciences research and engineering. Ansa Biotechnologies is developing a DNA synthesis technology that use enzymatic DNA synthesis to make DNA.

Soon after the discovery of polymerase enzymes that copy DNA, scientists have attempted to use a polymerase to write a desired sequences. One particular polymerase, Terminal Deoxynucleotidyl Transferase (TdT), has been considered the prime candidate for this purpose because, unlike other polymerases that copy an existing sequence, TdT creates random DNA. In order to use TdT for the synthesis of a desired sequence, its activity must be controlled so that it adds a single base to a DNA molecule and then stops, so the desired sequence can be synthesized step-by-step. Proposals to employ TdT for the stepwise synthesis of desired sequences date back to the early 1960s. However, controlling TdT's additions while maintaining its incorporation kinetics has proven to be difficult. Ansa are developing a technique to control additions of a polymerase that use TdT for de novo DNA synthesis.

The technology is based on polymerase-nucleotide conjugates that enable single nucleotide addition by a polymerase.

Timeline

People

Name
Role
Related Golden topics

Daniel H Arlow

Co-founder

DNA synthesis

Sebastian Palluk

Co-founder

DNA synthesis

Further reading

Title
Author
Link
Type

A new route to synthetic DNA

Adam Clore

Journal

De novo DNA synthesis using polymerase-nucleotide conjugates

Sebastian Palluk, Daniel H Arlow, Tristan de Rond, Sebastian Barthel, Justine S Kang, Rathin Bector, Hratch M Baghdassarian, Alisa N Truong, Peter W Kim, Anup K Singh, Nathan J Hillson, Jay D Keasling

Journal

New technique could help scientists create a gene in just 1 day

Robert Service

Web

Researchers pioneer DNA synthesis method that creates genes faster

Madeleine Gregory

Web

Documentaries, videos and podcasts

Title
Date
Link

Faster, Cheaper, Better: A New Way to Synthesize DNA

Companies

Company
CEO
Location
Products/Services

References