Amino acid

Amino acids are organic compounds that contain amino (-NH₂) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid. The elements present in every amino acid are carbon (C), hydrogen (H), oxygen (O), and nitrogen (N); in addition, sulfur (S) is present in the side chains of cysteine and methionine. Selenium is an essential trace element in the amino acid selenocysteine, which is incorporated into 25 human proteins (selenoproteins). Amino acids are used by biological organisms in cellular metabolism and synthesis of protein. Amino acids function as energy metabolites and in communication between cells. More than 500 amino acids have been discovered in nature, but only 22 of them participate in translation, the synthesis of protein from the nucleic acid code in mRNA. Twenty amino acids are used in proteins in all living organisms but selenocysteine and pyrrolysine are not used by all organisms. The human body needs 20 different types of amino acids to function property, nine9 of which the body cannot synthesize. These are called essential amino acids, because they must be acquired from food.

The 20 naturally occurring acids used in protein synthesis are represented by the generic formula above (image from Aouniti, A. et al. (2017). Amino acid compounds as eco-friendly corrosion inhibitor in acidic media-Review). The alpha carbon (α-carbon or Cα) shown in the centre connects the amino group to the acid carboxyl group. The alpha carbon is the point of attachment for the sidechainsside chains of 19 out of 20 amino acids used to build proteins. Glycine, the only amino acid with no sidechainside chain, has a hydrogen atom in the location of the sidechainside chain in other amino acids. When incorporated into protein, all of these 20 amino acids are L-isomer, alpha-amino acids with an R-absolute configuration, except glycine (no chiral center) and cysteine, which has an S-absolute configuration due to the sulfur-containing R-group. Selenocysteine and pyrrolysine are considered the 21sttwenty-first and 22ndtwenty-second amino acids. Humans use selenocysteine, but not pyrrolysine. Both of these more recently discovered amino acids are thought to be incorporated into protein during ribosomal protein synthesis, which is different than the other 20.

All of the canonical amino acids, except glycine, exist in two optically active forms, D- and L-, which are called enantiomers, meaning they are mirror images of each other. D- (dextrorotatory) and L- (levorotatory) forms of amino acids have different physiological and biological activities. L-Amino acids are the building blocks of proteins in all kingdoms of life. D-Amino acids have fundamental roles in microbial physiology as key constituents of peptidoglycan, part of the bacterial cell wall. Diverse bacterial species release non-canonical D-amino acids into the environment, whichand these regulate cellular processedprocesses in the producer and other bacteria within the niche.

Histidine participates in synthesizing the neurotransmitter, histamine, which functionfunctions in the immune system, digestion, sleep, and sexual function.

Isoleucine functions in muscle metabolism, the immune system, hemoglobin synthesis, and energy regulation.

Leucine assists in the production of growth hormones, muscle growth and repair, wound healing, and energy production as an involvement in calcium and immune function.

Methionine is involved in tissue growth, metabolism, and detoxification as well as absorption of essential minerals such as zinc and selenium.

Pheylalanine has an essential role in production of neurotransmitters, including dopamine, epinephrine, and norepinephrine, and in the production of other amino acids.

Threonine has a role in collagen and elastin production needed for skin and connective tissue, blood clot formation, fat metabolism, and immune function.

Valine is involved in muscle growth, tissue regeneration, and the production of energy.

The 11 nonessential amino acids are alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, proline, serine, and tyrosine. Amino acids that are considered essential when a person is ill or stressed out are called conditional amino acids. Conditional amino acids include arginine, cysteine, glutamine, tyrosine, glycine, ornithine, proline, and serine.

• L-glutamate, ionic form of the amino acid glutamic acid, is the main excitatory neurotransmitter in the central nervous system (CNS). Nerves that signal via L-glutamate, glutamatergic synapses, account for 80-90% percent of synapses in the brain and 60% percent of synapses in the CNS.
• Both enantiomers of serine, L-Serine, and D-Serine are neurologically active. L-Serine is synthesized in the brain by astrocytes and deficiencies in this molecule have been linked to developmental disorders and neuropathies.

The 20 naturally occurring acids used in protein synthesis are represented by the generic formula above (image from Aouniti, A. et al. (2017). Amino acid compounds as eco-friendly corrosion inhibitor in acidic media-Review). The alpha carbon (α-carbon or Cα) shown in the centre connects the amino group to the acid carboxyl group. The alpha carbon is the point of attachment for the sidechains of 19 out of 20 amino acids used to build proteins. Glycine, the only amino acid with no sidechain has a hydrogen atom in the location of the sidechain in other amino acids. AllWhen incorporated into protein, all of these 20 amino acids are L-isomer, alpha-amino acids with an R-absolute configuration except glycine (no chiral center) and cysteine which ashas an S-absolute configuration due to the sulfur-containing R-group. Selenocysteine and pyrrolysine are considered the 21st and 22nd amino acids. Humans use selenocysteine but not pyrrolysine. Both of these more recently discovered amino acids are thought to be incorporated into protein during ribosomal protein synthesis which is different than the other 20.

All of the canonical amino acids except glycine exist in two optically active forms, D- and L-, which are called enantiomers, meaning they are mirror images of each other. D- (dextrorotatory) and L- (levorotatory) forms of amino acids have different physiological and biological activities. L-Amino acids are the building blocks of proteins in all kingdoms of life. D-Amino acids have fundamental roles in microbial physiology as key constituents of peptidoglycan, part of the bacterial cell wall. Diverse bacterial species release non-canonical D-amino acids into the environment which regulate cellular processed in the producer and other bacteria within the niche.

All 20 amino acids have roles in the nervous system. L-glutamate, ionic form of the amino acid glutamic acid, is the main excitatory neurotransmitter in the central nervous system (CNS). Nerves that signal via L-glutamate, glutamatergic synapses, account for 80-90% of synapses in the brain and 60% of synapses in the CNS. Aspartate is a structural homologue of glutamate, which may function as a neurotransmitter. Glutamine participates as a neurotransmitter in the glutamate/GABA-glutamine cycle, in astrocyte cells.

All 20 amino acids have roles in the nervous system. Examples of amino acids that function in the nervous system:

• L-glutamate, ionic form of the amino acid glutamic acid, is the main excitatory neurotransmitter in the central nervous system (CNS). Nerves that signal via L-glutamate, glutamatergic synapses, account for 80-90% of synapses in the brain and 60% of synapses in the CNS.
• Aspartate is a structural homologue of glutamate, which may function as a neurotransmitter. Glutamine participates as a neurotransmitter in the glutamate/GABA-glutamine cycle, in astrocyte cells.
• L-Cysteine is a precursor for glutathione, the body’s main antioxidant. L-Cysteine can also be released by neuron depolarization in a Ca2+ dependent manner, activate NMDA receptors and be taken up by neurons and glia.
• L-Proline is a non-essential amino acid that can be synthesized from L-glutamate. L-Proline is a neuromodulator and fulfills many criteria for a neurotransmitter. Hyperprolinemia is a genetic condition that causes impaired proline metabolism which results in high levels of proline. Symptoms of the condition include seizures, hypolocomotion, learning and other cognitive deficits and an increased risk of schizophrenia.
• γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain and is not used in proteogenesis. GABA is synthesized from glutamate by glutamate decarboxylase. Aberrant GABA signaling is implicated in epilepsy, late-stage Alzheimer’s disease, anxiety disorders, schizophrenia and Huntington’s disease.
• L-Lysine is transported into the CNS by multiple amino acid transporters and has neuromodulatory effects on GABAergic transmission of nerve sigals.
• Both enantiomers of serine, L-Serine and D-Serine are neurologically active. L-Serine is synthesized in the brain by astrocytes and deficiencies in this molecule have been linked to developmental disorders and neuropathies.

All 20 amino acids have roles in the nervous system. L-glutamate, ionic form of the amino acid glutamic acid, is the main excitatory neurotransmitter in the central nervous system (CNS). Nerves that signal via L-glutamate, glutamatergic synapses, account for 80-90% of synapses in the brain and 60% of synapses in the CNS. Aspartate is a structural homologue of glutamate, which may function as a neurotransmitter. Glutamine participates as a neurotransmitter in the glutamate/GABA-glutamine cycle, in astrocyte cells.

All 20 amino acids have roles in the nervous system. L-glutamate is the main excitatory neurotransmitter in the central nervous system (CNS). Nerves that signal via L-glutamate, glutamatergic synapses, account for 80-90% of synapses in the brain and 60% of synapses in the CNS. Aspartate is a structural homologue of glutamate, which may function as a neurotransmitter. Glutamine participates as a neurotransmitter in the glutamate/GABA-glutamine cycle, in astrocyte cells.

Amino acids are organic compounds that contain amino (-NH₂) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid. The elements present in every amino acid are carbon (C), hydrogen (H), oxygen (O), and nitrogen (N); in addition sulfur (S) is present in the side chains of cysteine and methionine. Selenium is an essential trace element in the amino acid selenocysteine which is incorporated into 25 human proteins (selenoproteins). Amino acids are used by biological organisms in cellular metabolism and synthesis of protein. Amino acids function as energy metabolites and in communication between cells. More than 500 amino acids have been discovered in nature but only 22 of them participate in translationtranslation, the synthesis of protein from the nucleic acid code in mRNA. Twenty amino acids are used in proteins in all living organisms but selenocysteine and pyrrolysine are not used by all organisms. The human body needs 20 different types of amino acids to function property, nine of which the body cannot synthesize. These are called essential amino acids because they must be acquired from food.

Amino acids join together in long chains to form proteins, which are polymers of alpha-amino acids. Proteins assemble via amide bonds known as peptide linkages. Different proteins have different compositions and arrangements of amino acids.

The 20 naturally occurring acids used in protein synthesis are represented by the generic formula above (image from Aouniti, A. et al. (2017). Amino acid compounds as eco-friendly corrosion inhibitor in acidic media-Review). The alpha carbon (α-carbon or Cα) shown in the centre connects the amino group to the acid carboxyl group. The alpha carbon is the point of attachment for the sidechains of 19 out of 20 amino acids used to build proteins. Glycine, the only amino acid with no sidechain has a hydrogen atom in the location of the sidechain in other amino acids. All of these 20 amino acids are L-isomer, alpha-amino acids with an R-absolute configuration except glycine (no chiral center) and cysteine which as an S-absolute configuration due to the sulfur-containing R-group. Selenocysteine and pyrrolysine are considered the 21st and 22nd amino acids. Humans use selenocysteine but not pyrrolysine. Both of these more recently discovered amino acids are thought to be incorporated into protein during ribosomal protein synthesis which is different than the other 20.

Amino acids are organic compounds that contain amino (-NH₂) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid. The elements present in every amino acid are carbon (C), hydrogen (H), oxygen (O), and nitrogen (N); in addition sulfur (S) is present in the side chains of cysteine and methionine. Selenium is an essential trace element in the amino acid selenocysteine which is incorporated into 25 human proteins (selenoproteins). Amino acids are used by biological organisms in cellular metabolism and synthesis of protein. Amino acids function as energy metabolites and in communication between cells. More than 500 amino acids have been discovered in nature but only 22 of them participate in translation, the synthesis of protein from the nucleic acid code in mRNA. Twenty amino acids are used in proteins in all living organisms but selenocysteine and pyrrolysine are not used by all organisms. The human body needs 20 different types of amino acids to function property, nine of which the body cannot synthesize. These are called essential amino acids because they must be acquired from food.

The 20 naturally occurring acids used in protein synthesis are represented by the generic formula above (image from Aouniti, A. et al. (2017). Amino acid compounds as eco-friendly corrosion inhibitor in acidic media-ReviewAmino acid compounds as eco-friendly corrosion inhibitor in acidic media-Review). The alpha carbon (α-carbon or Cα) shown in the centre connects the amino group to the acid carboxyl group. The alpha carbon is the point of attachment for the sidechains of 19 out of 20 amino acids used to build proteins. Glycine, the only amino acid with no sidechain has a hydrogen atom in the location of the sidechain in other amino acids.

Histidine participates in synthesizing the neurotransmitter, histamine, which function in the immune system, digestion, sleep and sexual function.

Isoleucine functions in muscle metabolism, the immune system, hemoglobin synthesis and energy regulation.

Leucine assists in the production of growth hormones, muscle growth and repair, wound healing and energy production as an involvement in calcium and immune function.

Methionine is involved in tissue growth, metabolism and detoxification as well as absorption of essential minerals such as zinc and selenium.

Pheylalanine has an essential role in production of neurotransmitters, dopamine, epinephrine and norepinephrine and in the production of other amino acids.

Threonine has a role in collagen and elastin production needed for skin and connective tissue, blood clot formation, fat metabolism and immune function.

Tryptophan is involved in nitrogen balance in the body and in the production of the neurotransmitter serotonin.

Valine is involved in muscle growth, tissue regeneration and production of energy.

The 11 nonessential amino acids are alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, proline, serine and tyrosine. Amino acids that are considered essential when a person is ill or stressed out are called conditional amino acids. Conditional amino acids include arginine, cysteine, glutamine, tyrosine, glycine, ornithine, proline and serine.

Amino acids are organic compounds that contain amino (-NH₂)and carboxylatecarboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid. The elements present in every amino acid are carbon (C), hydrogen (H), oxygen (O), and nitrogen (N); in addition sulfur (S) is present in the side chains of cysteine and methionine,. Selenium is an essential trace element in andthe seleniumamino acid selenocysteine which is incorporated into 25 human proteins (Seselenoproteins) in the less common amino acid selenocysteine. More than 500 naturally occurring amino acids are known tohave constitutebeen monomerdiscovered unitsin ofnature peptides, including proteins, as of 2020 (thoughbut only 22 of them participate in translation, the synthesis of protein from the nucleic acid code in mRNA. The human body needs 20 appeardifferent types of amino acids to function property, nine of inwhich the geneticbody code,cannot plussynthesize. selenocysteine,These whichare iscalled encodedessential inamino acids because they amust be acquired specialfrom way)food.

Generic L-amino acid

The 20 naturally occurring acids used in protein synthesis are represented by the generic formula above (image from Aouniti, A. et al. (2017). Amino acid compounds as eco-friendly corrosion inhibitor in acidic media-Review). The alpha carbon (α-carbon or Cα) shown in the centre connects the amino group to the acid carboxyl group. The alpha carbon is the point of attachment for the sidechains of 19 out of 20 amino acids used to build proteins. Glycine, the only amino acid with no sidechain has a hydrogen atom in the location of the sidechain in other amino acids.

Amino acids are organic compounds that contain amino and carboxylate functional groups, along with a side chain (R group) specific to each amino acid. The elements present in every amino acid are carbon (C), hydrogen (H), oxygen (O), and nitrogen (N); in addition sulfur (S) is present in the side chains of cysteine and methionine, and selenium (Se) in the less common amino acid selenocysteine. More than 500 naturally occurring amino acids are known to constitute monomer units of peptides, including proteins, as of 2020 (though only 20 appear in the genetic code, plus selenocysteine, which is encoded in a special way).

Generic L-amino acid