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US Patent 9901616 Apoptosis-targeting nanoparticles

Patent 9901616 was granted and assigned to UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. on February, 2018 by the United States Patent and Trademark Office.

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Patent
Patent

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Current Assignee
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
9901616
Date of Patent
February 27, 2018
Patent Application Number
14240081
Date Filed
August 31, 2012
Patent Citations Received
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US Patent 11690920 General and direct method for preparing oligonucleotide-functionalized metal-organic framework nanoparticles
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US Patent 11957788 Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
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US Patent 11883535 Liposomal particles, methods of making same and uses thereof
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US Patent 11696954 Synthesis of spherical nucleic acids using lipophilic moieties
0
Patent Primary Examiner
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Robert Cabral
Patent abstract

Nanoparticles include a core and one or more targeting moieties, as well as one or more contrast agents or one or more therapeutic agents. The contrast agents or therapeutic agents may be contained or embedded within the core. If the nanoparticle includes therapeutic agents, the agents are preferably released from the core at a desired rate. The core may be biodegradable and may release the agents as the core is degraded or eroded. The targeting moieties preferably extend outwardly from the core so that they are available for interaction with cellular components, which interactions will target the nanoparticles to the appropriate cells, such as apoptotic cells; organelles, such as mitochondria; or the like. The targeting moieties may be tethered to the core or components that interact with the core.

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