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Oxford Nanopore Technologies

Oxford Nanopore Technologies

DNA sequencing company specializing in rapid long-read sequencing through nanopores.

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Edits on 20 Jun, 2019
"I've learned from public ONT talks that the membrane they embed the pore in is not a traditional phospholipid bilayer"
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Isaac Larkin
edited on 20 Jun, 2019
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Oxford Nanopore Technologies (also known as Oxford Nanopore) is a British biotechnology company that produces machines and kits for nanopore sequencing of both DNA and RNA. Oxford Nanopore's sequencing technology is based on measuring the voltage across a lipid membrane as a motor protein threads a single strand of nucleic acid through a transmembrane protein pore. This approach to reading DNA enables Oxford Nanopore to build small, low-power, inexpensive DNA sequencers; to sequence extremely long strands of DNA; and to perform rapid DNA sequence detection and analysis. These characteristics have lead to the use of Oxford Nanopore devices to perform genetic analysis in remote or extreme environments, such as deep in a rainforest or on the International Space Station; and to their use for rapid detection, diagnosis and analysis of pathogens in the field, such as during the 2014-15 Ebola outbreak in West Africa.

Edits on 13 Jun, 2018
"Clarified that ONT can sequence both DNA and RNA"
Isaac Larkin profile picture
Isaac Larkin
edited on 13 Jun, 2018
Edits made to:
Article (+26/-10 characters)
Article

Oxford Nanopore Technologies is a British biotechnology company that produces machines and kits for nanopore sequencing of both DNA sequencingand RNA. Oxford Nanopore's sequencing technology is based on measuring the voltage across a lipid membrane as a motor protein threads a single strand of nucleic acid through a transmembrane protein pore. This approach to reading DNA enables Oxford Nanopore to build small, low-power, inexpensive DNA sequencers; to sequence extremely long strands of DNA; and to perform rapid DNA sequence detection and analysis. These characteristics have lead to the use of Oxford Nanopore devices to perform genetic analysis in remote or extreme environments, such as deep in a rainforest or on the International Space Station; and to their use for rapid detection, diagnosis and analysis of pathogens in the field, such as during the 2014-15 Ebola outbreak in West Africa.

Isaac Larkin profile picture
Isaac Larkin
edited on 13 Jun, 2018
Edits made to:
Article (-32 characters)
Article

Oxford Nanopore Technologies is a British biotechnology company that produces machines and kits for nanopore DNA sequencing. The stated goal of the company Oxford Nanopore's sequencing technology is based on measuring the voltage across a lipid membrane as a motor protein threads a single strand of nucleic acid through a transmembrane protein pore. This approach to reading DNA enables Oxford Nanopore to build small, low-power, inexpensive DNA sequencers; to sequence extremely long strands of DNA; and to perform rapid DNA sequence detection and analysis. These characteristics have lead to the use of Oxford Nanopore devices to perform genetic analysis in remote or extreme environments, such as deep in a rainforest or on the International Space Station; and to their use for rapid detection, diagnosis and analysis of pathogens in the field, such as during the 2014-15 Ebola outbreak in West Africa.

"Creating an MVP for ONT"
Isaac Larkin profile picture
Isaac Larkin
edited on 13 Jun, 2018
Edits made to:
Description (+157 characters)
Article (+1130 characters)
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Oxford Nanopore Technologies

DNA sequencing company specializing in rapid long-read sequencing through nanopores, whose stated goal is to enable 'anyone, to sequence anything, anywhere.'

Article

Oxford Nanopore Technologies is a British biotechnology company that produces machines and kits for nanopore DNA sequencing. The stated goal of the company Oxford Nanopore's sequencing technology is based on measuring the voltage across a lipid membrane as a motor protein threads a single strand of nucleic acid through a transmembrane protein pore. This approach to reading DNA enables Oxford Nanopore to build small, low-power, inexpensive DNA sequencers; to sequence extremely long strands of DNA; and to perform rapid DNA sequence detection and analysis. These characteristics have lead to the use of Oxford Nanopore devices to perform genetic analysis in remote or extreme environments, such as deep in a rainforest or on the International Space Station; and to their use for rapid detection, diagnosis and analysis of pathogens in the field, such as during the 2014-15 Ebola outbreak in West Africa.

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While the basecalling accuracy of Oxford Nanopore sequencers remains lower than those achievable by Sanger or Illumina sequencing, both per-read and consensus assembly accuracy have rapidly improved in the past few years.

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