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Molecular biology

Molecular biology

Molecular biology is a branch of biology that deals with the molecular basis of biological activity.

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Edits on 11 Sep, 2023
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Meredith Hanel
edited on 11 Sep, 2023
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Timeline (+2 events) (+203 characters)
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Biochemistry and molecular biology: Overlapping and distinguishing aspects

Molecular biology attempts to describe biological phenomena in terms of molecular interactions and encompasses research from the areas of biochemistry, microbiology, genetics and immunology. Biochemistry is focused on the chemistry of living organisms and seeks to explain the properties of living organisms in terms of their chemical substances. Molecular biology emerged when scientists with different expertise directed their attention to understanding life at a molecular level. Because molecular biologists do not necessarily have the level of chemistry training that biochemists have, there have been objections to the term “molecular biology”. Erwin Chargaff a biochemist at Columbia University joked, “Molecular Biology is the practice of biochemistry without a license.” On the other hand, molecular biology is a convenient term to describe a research field that combines a variety of disciplines. Francis Crick said that he started calling himself a molecular biologist because, “I got tired of explaining that I was a mixture of crystallographer, biophysicist, biochemist and geneticist”.

Both biochemists and molecular biologists strive to understand the basis of life. Biochemists approach this through the isolation of and characterization of chemical substances, derived from their fragmentation. Molecular biologists are usually more interested in phenomena and deal more often with whole cells and organisms. Molecular biology and biochemistry have enough in common that many departments and societies couple them together.

Timeline

1965

"Molecular Biology of the Gene" was published in 1965 by James D. Watson.

1938

Warren Weaver, the director of the Natural Sciences section of the Rockefeller Foundation, introduced the term “molecular biology”
Edits on 9 Sep, 2023
Meredith Hanel profile picture
Meredith Hanel
edited on 9 Sep, 2023
Edits made to:
Article (+139/-32 characters)
Article

The science field of molecular biology concernsis concerned with chemical structures, molecular compositions, interactions between molecules and biological processes of biological phenomena that involve molecules such as nucleic acids (DNA and RNA) and proteins, which are essential for cell function and maintenance. Molecular biology developed out of the related fields of biochemistry, genetics and biophysics, emerging in the 1930s. Molecular biologists seek answers to questions about molecular structures and the association between genes and characteristics of an organism. Methods used in molecular biology, such as recombinant DNA technology, polymerase chain reaction and DNA sequencing, allow scientists to isolate, characterize and modify specific genes in order to study them.

Meredith Hanel profile picture
Meredith Hanel
edited on 9 Sep, 2023
Edits made to:
Article (+650 characters)
Article

The science field of molecular biology concerns chemical structures and processes of biological phenomena that involve molecules such as nucleic acids (DNA and RNA) and proteins. Molecular biology developed out of the related fields of biochemistry, genetics and biophysics, emerging in the 1930s. Molecular biologists seek answers to questions about molecular structures and the association between genes and characteristics of an organism. Methods used in molecular biology, such as recombinant DNA technology, polymerase chain reaction and DNA sequencing, allow scientists to isolate, characterize and modify specific genes in order to study them.

Meredith Hanel profile picture
Meredith Hanel
edited on 9 Sep, 2023
Edits made to:
Timeline (+2 events) (+417 characters)
Timeline

1971

Kathleen Danna and Daniel Nathans first demonstrated the utility of restriction enzymes for producing specific fragments of DNA that could be separated by electrophoresis. Restriction enzymes became the workhorses of molecular biology.

1953

The structure of DNA was described in three papers by seven authors: Rosalind Franklin, Raymond Gosling, Maurice Wilkins, Alec Stokes, Herbert Wilson, James Watson and Francis Crick.

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